Quantification of Linear and Nonlinear Cardiorespiratory Interactions under Autonomic Nervous System Blockade

Varon, C. ; Hendrikx, D. ; Bolea, J. ; Laguna, P. ; Bailón, R. (Universidad de Zaragoza)

Resumen: This paper proposes a methodology to extract both linear and nonlinear respiratory influences from the heart rate variability (HRV), by decomposing the HRV into a respiratory and a residual component. This methodology is based on least-squares support vector machines (LS-SVM) formulated for nonlinear function estimation. From this decomposition, a better estimation of the respiratory sinus arrhythmia (RSA) and the sympathovagal balance (SB) can be achieved. These estimates are first analyzed during autonomic blockade and an orthostatic maneuver, and then compared against the classical HRV and a model that considers only linear interactions. Results are evaluated using surrogate data analysis and they indicate that the classical HRV and the linear model underestimate the cardiorespiratory interactions. Moreover, the linear and nonlinear interactions appear to be mediated by different control mechanisms. These findings will allow to better assess the ANS and to improve the understanding of the interactions within the cardiorespiratory system.

Idioma: Inglés

DOI: 10.23919/CinC49843.2019.9005628

Año: 2019

Publicado en: Computing in Cardiology 46 (2019), [4 pp]
ISSN: 2325-8861

Factor impacto SCIMAGO: 0.296 - Computer Science (miscellaneous) - Cardiology and Cardiovascular Medicine

Financiación: info:eu-repo/grantAgreement/EC/FP7/339804/EU/Biomedical Data Fusion using Tensor based Blind Source Separation/BIOTENSORS
Financiación: info:eu-repo/grantAgreement/ES/MINECO-FEDER/RTI2018-097723-B-I00

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Teoría Señal y Comunicac. (Dpto. Ingeniería Electrón.Com.)