doi:10.23919/CinC49843.2019.9005904engPalmieri, F.Ramírez, J.Laguna, P.Gomis, P.Ferreira, D.Ruiz, J.E.Bergasa, B.Martín-Yebra, A.Bukhari, H.A.Pueyo, E.Martínez, J.P.T-Wave Morphology Changes as Surrogate for Blood Potassium Concentration in Hemodialysis PatientsART-2019-122005End-stage renal disease (ESRD) patients undergoing hemodialysis (HD) are at high risk of arrhythmias and sudden cardiac death as a result of blood potassium concentration ([K+ ]) changes. The aim of this study is to investigate if dw, a time-warping-based electrocardiogram (ECG) biomarker of T-wave morphology changes, reflects [K+] evolution in HD patients, facilitating noninvasive [K+] monitoring and avoiding in-hospital blood tests analysis. 48-hour ECGs and a set of hourly-collected blood samples from 12 ESRD patients were acquired and analyzed. dw was calculated between a reference T-wave, measured at the end of the HD session, and the T-waves corresponding to each hour along the whole HD session, when [K+] was measured from blood samples. The values of dw correlated with the relative variations in [K+] with respect to the reference value (end of HD, ¿[K+ ]), with a median (interquartile) correlation coefficient of 0.90 (0.30), evidencing a strong relation between them. Our findings support the use of dw as a surrogate of ¿[K+], suggesting a potential use of dw for non-invasive hyperkalemia monitoring both in hospital and ambulatory settings.2019http://zaguan.unizar.es/record/9828710.23919/CinC49843.2019.9005904http://zaguan.unizar.es/record/98287oai:zaguan.unizar.es:98287info:eu-repo/grantAgreement/ES/DGA-FEDER/T39-17R-BSICoSinfo:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284info:eu-repo/grantAgreement/EC/H2020/786833/EU/GENetics and the Electrocardiogram for predicting Scd rISk/GENESISThis project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 786833-GENESISinfo:eu-repo/grantAgreement/ES/MINECO-FEDER/DPI2016-75458-RComputing in Cardiology 46 (2019), [4 pp]byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess