98287 20230914083307.0 doi 10.23919/CinC49843.2019.9005904 sideral 122005 ART-2019-122005 eng Palmieri, F. T-Wave Morphology Changes as Surrogate for Blood Potassium Concentration in Hemodialysis Patients 2019 Access copy available to the general public Unrestricted End-stage renal disease (ESRD) patients undergoing hemodialysis (HD) are at high risk of arrhythmias and sudden cardiac death as a result of blood potassium concentration ([K+ ]) changes. The aim of this study is to investigate if dw, a time-warping-based electrocardiogram (ECG) biomarker of T-wave morphology changes, reflects [K+] evolution in HD patients, facilitating noninvasive [K+] monitoring and avoiding in-hospital blood tests analysis. 48-hour ECGs and a set of hourly-collected blood samples from 12 ESRD patients were acquired and analyzed. dw was calculated between a reference T-wave, measured at the end of the HD session, and the T-waves corresponding to each hour along the whole HD session, when [K+] was measured from blood samples. The values of dw correlated with the relative variations in [K+] with respect to the reference value (end of HD, ¿[K+ ]), with a median (interquartile) correlation coefficient of 0.90 (0.30), evidencing a strong relation between them. Our findings support the use of dw as a surrogate of ¿[K+], suggesting a potential use of dw for non-invasive hyperkalemia monitoring both in hospital and ambulatory settings. info:eu-repo/grantAgreement/ES/DGA-FEDER/T39-17R-BSICoS info:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284 info:eu-repo/grantAgreement/EC/H2020/786833/EU/GENetics and the Electrocardiogram for predicting Scd rISk/GENESIS This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 786833-GENESIS info:eu-repo/grantAgreement/ES/MINECO-FEDER/DPI2016-75458-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 0.296 2019 Computer Science (miscellaneous) 2019 Cardiology and Cardiovascular Medicine 2019 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Ramírez, J. Laguna, P. Universidad de Zaragoza (orcid)0000-0003-3434-9254 Gomis, P. Ferreira, D. Ruiz, J.E. Universidad de Zaragoza (orcid)0000-0002-4351-8518 Bergasa, B. Martín-Yebra, A. Bukhari, H.A. Universidad de Zaragoza (orcid)0000-0001-5976-0483 Pueyo, E. Universidad de Zaragoza (orcid)0000-0002-1960-407X Martínez, J.P. Universidad de Zaragoza (orcid)0000-0002-7503-3339 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 46 (2019), [4 pp] Comput. cardiol. Computing in Cardiology 2325-8861 239360 http://zaguan.unizar.es/record/98287/files/texto_completo.pdf Versión publicada 2625704 http://zaguan.unizar.es/record/98287/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:98287 articulos driver 2023-09-13-10:56:10 ARTICLE