000098315 001__ 98315 000098315 005__ 20210126103232.0 000098315 0248_ $$2sideral$$a122057 000098315 037__ $$aART-2019-122057 000098315 041__ $$aeng 000098315 100__ $$aGardeazabal, L. 000098315 245__ $$aHuman breast milk exosomes accelerate mouse wound healing 000098315 260__ $$c2019 000098315 5060_ $$aAccess copy available to the general public$$fUnrestricted 000098315 5203_ $$aP543 The healing of cutaneous wounds is a very efficient process despite being very complex. Under certain pathological conditions healing may be impaired, prolonging the healing process and eventually leading to medical intervention and the chronicity of the wound. Exosomes are secreted extracellular vesicles present in biological fluids where they play a key role in intercellular communication at the tissue, organ and organismal levels. Given that human breast milk contains abundant maternal extracellular vesicles (MEVs) with pro-regenerative and immunomodulatory properties, the aim of the present study was to evaluate if topical application ofMEVs into open wounds would be beneficial for healing. Full-thickness excision wounds of 4-mm diameter were created in the dorsal skin of C57BL/6 mice and topical application of 20 micrograms of human MEV isolated at weeks 9, 11, 12 and 15 postpartum of breastfeeding were placed onto the open wounds. Control wounds were vehicle-treated. Macroscopic measurements up to 7 days postwounding revealed that the area of the wound treated with MEV significantly decreased compared with controls. Histological analyses at day 7 post-wounding showed no differences in the granulation tissue area between groups. ... 000098315 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000098315 590__ $$a4.273$$b2019 000098315 591__ $$aBIOTECHNOLOGY & APPLIED MICROBIOLOGY$$b30 / 156 = 0.192$$c2019$$dQ1$$eT1 000098315 591__ $$aGENETICS & HEREDITY$$b38 / 177 = 0.215$$c2019$$dQ1$$eT1 000098315 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b40 / 138 = 0.29$$c2019$$dQ2$$eT1 000098315 592__ $$a1.648$$b2019 000098315 593__ $$aGenetics$$c2019$$dQ1 000098315 593__ $$aMolecular Medicine$$c2019$$dQ1 000098315 593__ $$aMolecular Biology$$c2019$$dQ2 000098315 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion 000098315 700__ $$aYndriago, L. 000098315 700__ $$aPrieto, I. 000098315 700__ $$aCrespo-Barreda, A. 000098315 700__ $$0(orcid)0000-0003-4160-9720$$aMartin-Duque, P. 000098315 700__ $$aAldazabal, J. 000098315 700__ $$aParedes, J. 000098315 700__ $$aIzeta, A. 000098315 773__ $$g30, 11 (2019), A178$$pHum. gene ther.$$tHUMAN GENE THERAPY$$x1043-0342 000098315 85641 $$uhttps://www.liebertpub.com/doi/pdf/10.1089/hum.2019.29095.abstracts$$zTexto completo de la revista 000098315 8564_ $$s44268$$uhttps://zaguan.unizar.es/record/98315/files/texto_completo.pdf$$yVersión publicada 000098315 8564_ $$s3526129$$uhttps://zaguan.unizar.es/record/98315/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000098315 909CO $$ooai:zaguan.unizar.es:98315$$particulos$$pdriver 000098315 951__ $$a2021-01-26-09:28:54 000098315 980__ $$aARTICLE