98334 20210126163933.0 sideral 122077 ART-2019-122077 eng (orcid)0000-0001-8762-5457 Sancho-Albero, M. Universidad de Zaragoza Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis 2019 Access copy available to the general public Unrestricted P151 The transformational impact of bioorthogonal chemistries has inspired new strategies for the in vivo synthesis of bioactive agents through non-natural means. Among these, Palladium (Pd) catalysts have played a prominent role in the growing subfield of bioorthogonal catalysis by producing xenobiotics and uncaging biomolecules in living systems, and new exciting Pdcatalyzed reactions and applications continue to emerge. However, delivering catalysts selectively to specific cell types still lags behind catalyst development. Towards this goal, we have developed a bio-artificial device consisting of cancer-derived exosomes loaded with Pd catalysts by a novelmethod that enables the controlled assembly of Pd nanosheets directly inside the vesicles. This new hybrid system mediates Pdtriggered dealkylation reactions in vitro and inside cells and displays preferential tropism for their progenitor cells. The use of Trojan exosomes to deliver abiotic catalysts into designated cancer cells creates the opportunity for a new targeted therapy modality: exosome-directed catalyst prodrug therapy, whose first steps are presented herein with the cell-specific release of the recently approved anticancer drug panobinostat. info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 4.273 2019 BIOTECHNOLOGY & APPLIED MICROBIOLOGY 30 / 156 = 0.192 2019 Q1 T1 GENETICS & HEREDITY 38 / 177 = 0.215 2019 Q1 T1 MEDICINE, RESEARCH & EXPERIMENTAL 40 / 138 = 0.29 2019 Q2 T1 1.648 2019 Genetics 2019 Q1 Molecular Medicine 2019 Q1 Molecular Biology 2019 Q2 info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion Rubio-Ruiz, B. Perez-Lopez, A.M. (orcid)0000-0002-6873-5244 Sebastian, V. Universidad de Zaragoza (orcid)0000-0003-4160-9720 Martin-Duque, P. (orcid)0000-0003-3165-0156 Arruebo, M. Universidad de Zaragoza Unciti-Broceta, A. (orcid)0000-0002-8701-9745 Santamaria, J. Universidad de Zaragoza 5005 555 Universidad de Zaragoza Dpto. Ing.Quím.Tecnol.Med.Amb. Área Ingeniería Química 30, 11 (2019), A63-A64 Hum. gene ther. HUMAN GENE THERAPY 1043-0342 https://www.liebertpub.com/doi/pdf/10.1089/hum.2019.29095.abstracts Texto completo de la revista 72064 http://zaguan.unizar.es/record/98334/files/texto_completo.pdf Versión publicada 3431252 http://zaguan.unizar.es/record/98334/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:98334 articulos driver 2021-01-26-15:09:08 ARTICLE