000098412 001__ 98412
000098412 005__ 20211216131138.0
000098412 0248_ $$2sideral$$a122174
000098412 037__ $$aART-2019-122174
000098412 041__ $$aeng
000098412 100__ $$0(orcid)0000-0001-9876-5850$$aAscaso, F.$$uUniversidad de Zaragoza
000098412 245__ $$aAssociation between mitochondrial haplogroups and ranibizumab response in neovascular age-related macular degeneration
000098412 260__ $$c2019
000098412 5060_ $$aAccess copy available to the general public$$fUnrestricted
000098412 5203_ $$aPurpose : The association between mitochondrial DNA (mtDNA) haplogroup and the risk of neovascular age-related macular degeneration (nAMD) has been reported. This prospective, observational clinical study analyzes the anatomical and functional outcomes after one year of intravitreal ranibizumab therapy in nAMD patients according to the mt-DNA haplogroup.
Methods : Ninety-eight eyes corresponding to 91 patients with nAMD were treated with three consecutive monthly intravitreal ranibizumab 0.5 mg followed by a flexible pro re nata (PRN). Retreatment criteria were: loss =5 ETDRS letters; increased central foveal thickness (CFT) >100 µm; intra or subretinal fluid on OCT; new or persistent macular haemorrhages. Exclusion criteria were previous treatment with photodynamic therapy or anti-VEGF drug; vitrectomy or any other retinal disease; corneal or lens opacities. Patients were classified into four groups according to their mtDNA haplogroup determined by PCR (Hg H- m.7028C>T; Hg HV- m.14766T>C; Hg JT- m.421 6T>C and Hg U- m.12308A>G). Chi-square, Kolmogorov-Smirnov, ANOVA, Mann-Whitney, Kruskal-Wallis, analysis of variance, Wilcoxon, and Friedman tests were used. SPSS 21.0 program. A p value < 0.05 was statistically significant.
Results : Gender, age, risk factors (smoking, diabetes, arterial hypertension and dyslipidemia) and neovascular lesion type were equally distributed among four groups. There were no significant differences between groups in baseline or after loading fase in best corrected visual acuity (BCVA) or CFT. At 4 months, BCVA was significantly higher than baseline in haplogroups HV (p = 0.02), JT (p = 0.002) and U (p = 0.002). CFT was significantly lower in all haplogroups (HV, p<0.001;JT, p=0.028;U, p=0.043;Others, p=0.007). Eighteen patients were excluded at 12 months because of exclusion criteria, however baseline variables were equally distributed among four groups. At 12 months, BCVA in HV and U did not show significant worsening; however, JT showed lower BCVA values than baseline. CFT values in JT were higher than baseline (p = 1.00), whereas HV and U were significantly lower than baseline (HV, p < 0.001; U, p = 0.007). CFT values were significantly different between JT and U (p = 0.010).
Conclusions : mtDNA haplogroups showed different response to ranibizumab at 12 month. It could be a potencial biomarker to predict the response to this therapy in nAMD patients.
000098412 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000098412 590__ $$a3.47$$b2019
000098412 591__ $$aOPHTHALMOLOGY$$b10 / 60 = 0.167$$c2019$$dQ1$$eT1
000098412 592__ $$a1.789$$b2019
000098412 593__ $$aOphthalmology$$c2019$$dQ1
000098412 593__ $$aSensory Systems$$c2019$$dQ1
000098412 593__ $$aCellular and Molecular Neuroscience$$c2019$$dQ2
000098412 655_4 $$ainfo:eu-repo/semantics/conferenceObject$$vinfo:eu-repo/semantics/publishedVersion
000098412 700__ $$aEsteban, O.
000098412 700__ $$0(orcid)0000-0003-1770-6299$$aMontoya, J.$$uUniversidad de Zaragoza
000098412 700__ $$aMontes, P.
000098412 700__ $$aMateo, J.
000098412 700__ $$aLara, J.
000098412 700__ $$0(orcid)0000-0002-0269-7337$$aRuiz-Pesini, E.$$uUniversidad de Zaragoza
000098412 7102_ $$11004$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía,Ginecol.Obstetr.$$cÁrea Oftalmología
000098412 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000098412 773__ $$g60, 9 (2019), [3 pp]$$pInvestig. ophthalmol. vis. sci.$$tInvestigative ophthalmology & visual science$$x0146-0404
000098412 85641 $$uhttps://iovs.arvojournals.org/article.aspx?articleid=2746228$$zTexto completo de la revista
000098412 8564_ $$s490633$$uhttps://zaguan.unizar.es/record/98412/files/texto_completo.pdf$$yVersión publicada
000098412 8564_ $$s1861811$$uhttps://zaguan.unizar.es/record/98412/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000098412 909CO $$ooai:zaguan.unizar.es:98412$$particulos$$pdriver
000098412 951__ $$a2021-12-16-13:05:24
000098412 980__ $$aARTICLE