98423 20210128133202.0 sideral 122185 ART-2019-122185 eng (orcid)0000-0001-5632-0351 Marron, S.E. Efficacy, safety and patient reported outcomes (PROS) in adult patients with atopic dermatitis treated with dupilumab at week-52 in usual clinical practice 2019 Access copy available to the general public Unrestricted P15 Background: Dupilumab, an anti-interleikin-4-receptor-a monoclonal antibody, is a new treatment for atopic dermatitis in adults. Objective: To evaluate – at week 52 – patient reported outcomes, satisfaction, efficacy and safety, with dupilumab in adult patients with moderate-to-severe atopic dermatitis refractory to the usual treatments previously performed under conditions of usual clinical practice. Methods: Twelve patients were enrolled. Patients from our hospital, under routine clinical practice, were treated with subcutaneous dupilumab 300 mg every 2 weeks. The outcomes were evaluated at baseline, week 4, 8, 12, 16, 28 , 40 and week 52. The variables evaluated were: itch, difficulty to sleep, previous stressful life events, severity (SCORAD), anxiety and depression symptoms (HADS), quality of life (DLQI, EQ5D3L), satisfaction, adherence to the treatment, efficacy and safety. Results: At week 52 significant improvement was observed in severity, itch, difficulty to sleep, anxiety and depression symptoms, and quality of life. Satisfaction with dupilumab compared to previous treatments was significantly higher in all aspects assessed. No significant dupilumab-induced laboratory abnormalities were noted, and adverse events were mild and transient. Conclusions: Dupilumab used under routine clinical practice for 52 weeks improved atopic dermatitis signs and symptoms, with a good safety profile and patient satisfaction. info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ 4.016 2019 DERMATOLOGY 7 / 68 = 0.103 2019 Q1 T1 1.01 2019 Medicine (miscellaneous) 2019 Q1 Dermatology 2019 Q1 info:eu-repo/semantics/conferenceObject info:eu-repo/semantics/publishedVersion Alcalde-Herrero, V.M. García Latasa de de Aranibar, F.J. Universidad de Zaragoza Moncin-Torres, C.A. Fuentelsaz del Barrio, M.V. (orcid)0000-0002-1691-3280 Alvarez-Salafranca, M. Universidad de Zaragoza (orcid)0000-0003-1917-6906 Tomas-Aragones, L. Universidad de Zaragoza 4009 735 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicolog.Evolut.Educac 1007 183 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Área Dermatología 99, 8 (2019), 751 Acta derm.-venereol. ACTA DERMATO-VENEREOLOGICA 0001-5555 https://www.medicaljournals.se/acta/download/10.2340/00015555-3228/ Texto completo de la revista 88579 http://zaguan.unizar.es/record/98423/files/texto_completo.pdf Versión publicada 4176705 http://zaguan.unizar.es/record/98423/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:98423 articulos driver 2021-01-28-12:42:39 ARTICLE