000099058 001__ 99058
000099058 005__ 20230519145437.0
000099058 0247_ $$2doi$$a10.3390/jpm11010025
000099058 0248_ $$2sideral$$a122309
000099058 037__ $$aART-2021-122309
000099058 041__ $$aeng
000099058 100__ $$aHermoso-Durán, S.
000099058 245__ $$aThermal liquid biopsy (TLB) focused on benign and premalignant pancreatic cyst diagnosis
000099058 260__ $$c2021
000099058 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099058 5203_ $$aBackground: Current efforts in the identification of new biomarkers are directed towards an accurate differentiation between benign and premalignant cysts. Thermal Liquid Biopsy (TLB) has been previously applied to inflammatory and tumor diseases and could offer an interesting point of view in this type of pathology.
Methods: In this work, twenty patients (12 males and 8 females, average ages 62) diagnosed with a pancreatic cyst benign (10) and premalignant (10) cyst lesions were recruited, and biological samples were obtained during the endoscopic ultrasonography procedure.
Results: Proteomic content of cyst liquid samples was studied and several common proteins in the different groups were identified. TLB cyst liquid profiles reflected protein content. Also, TLB serum score was able to discriminate between healthy and cysts patients (71% sensitivity and 98% specificity) and between benign and premalignant cysts (75% sensitivity and 67% specificity).
Conclusions: TLB analysis of plasmatic serum sample, a quick, simple and non-invasive technique that can be easily implemented, reports valuable information on the observed pancreatic lesion. These preliminary results set the basis for a larger study to refine TLB serum score and move closer to the clinical application of TLB providing useful information to the gastroenterologist during patient diagnosis.
000099058 536__ $$9info:eu-repo/grantAgreement/ES/DGA/E45-17R$$9info:eu-repo/grantAgreement/ES/FIS/PI15-00663$$9info:eu-repo/grantAgreement/ES/ISCIII/CIBERehd$$9info:eu-repo/grantAgreement/ES/ISCIII/CPII13-00017$$9info:eu-repo/grantAgreement/ES/ISCIII-ESF/Investing in your future$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/FI19-00146$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI18-00349$$9info:eu-repo/grantAgreement/ES/MCIU-AEI-FEDER/BFU2016-78232-P
000099058 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000099058 590__ $$a3.508$$b2021
000099058 592__ $$a0.757$$b2021
000099058 594__ $$a1.8$$b2021
000099058 591__ $$aMEDICINE, GENERAL & INTERNAL$$b69 / 172 = 0.401$$c2021$$dQ2$$eT2
000099058 593__ $$aMedicine (miscellaneous)$$c2021$$dQ2
000099058 591__ $$aHEALTH CARE SCIENCES & SERVICES$$b42 / 109 = 0.385$$c2021$$dQ2$$eT2
000099058 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000099058 700__ $$aGarcía-Rayado, G.
000099058 700__ $$aCeballos-Laita, L.
000099058 700__ $$0(orcid)0000-0001-7466-3876$$aSostres, C.$$uUniversidad de Zaragoza
000099058 700__ $$0(orcid)0000-0002-1232-6310$$aVega, S.
000099058 700__ $$aMillastre, J.
000099058 700__ $$aSánchez-Gracia, O.
000099058 700__ $$0(orcid)0000-0003-0853-2880$$aOjeda, J.L.$$uUniversidad de Zaragoza
000099058 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, Á.$$uUniversidad de Zaragoza
000099058 700__ $$0(orcid)0000-0001-5702-4538$$aVelázquez-Campoy, A.$$uUniversidad de Zaragoza
000099058 700__ $$0(orcid)0000-0001-5664-1729$$aAbian, O.$$uUniversidad de Zaragoza
000099058 7102_ $$12007$$2265$$aUniversidad de Zaragoza$$bDpto. Métodos Estadísticos$$cÁrea Estadís. Investig. Opera.
000099058 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000099058 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole.
000099058 773__ $$g11, 1 (2021), 25 [19 pp]$$pJ. pers. med.$$tJournal of Personalized Medicine$$x2075-4426
000099058 8564_ $$s690468$$uhttps://zaguan.unizar.es/record/99058/files/texto_completo.pdf$$yVersión publicada
000099058 8564_ $$s2681213$$uhttps://zaguan.unizar.es/record/99058/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000099058 909CO $$ooai:zaguan.unizar.es:99058$$particulos$$pdriver
000099058 951__ $$a2023-05-18-14:25:25
000099058 980__ $$aARTICLE