000099069 001__ 99069 000099069 005__ 20230330095434.0 000099069 0247_ $$2doi$$a10.1093/eurheartj/ehaa159 000099069 0248_ $$2sideral$$a122375 000099069 037__ $$aART-2020-122375 000099069 041__ $$aeng 000099069 100__ $$aCorral-Acero, J. 000099069 245__ $$aThe ''Digital Twin'' to enable the vision of precision cardiology 000099069 260__ $$c2020 000099069 5060_ $$aAccess copy available to the general public$$fUnrestricted 000099069 5203_ $$aProviding therapies tailored to each patient is the vision of precision medicine, enabled by the increasing ability to capture extensive data about individual patients. In this position paper, we argue that the second enabling pillar towards this vision is the increasing power of computers and algorithms to learn, reason, and build the ''digital twin'' of a patient. Computational models are boosting the capacity to draw diagnosis and prognosis, and future treatments will be tailored not only to current health status and data, but also to an accurate projection of the pathways to restore health by model predictions. The early steps of the digital twin in the area of cardiovascular medicine are reviewed in this article, together with a discussion of the challenges and opportunities ahead. We emphasize the synergies between mechanistic and statistical models in accelerating cardiovascular research and enabling the vision of precision medicine. 000099069 536__ $$9info:eu-repo/grantAgreement/EC/H2020/675451/EU/A Centre of Excellence in Computational Biomedicine/CompBioMed$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 675451-CompBioMed$$9info:eu-repo/grantAgreement/EC/H2020/764738/EU/Personalised In-Silico Cardiology/PIC$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 764738-PIC$$9info:eu-repo/grantAgreement/EC/H2020/766082/EU/MultidisciplinarY training network for ATrial fibRillation monItoring, treAtment and progression/MY-ATRIA$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 766082-MY-ATRIA$$9info:eu-repo/grantAgreement/EC/H2020/823712/EU/A Centre of Excellence in Computational Biomedicine/CompBioMed2$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 823712-CompBioMed2 000099069 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000099069 590__ $$a29.983$$b2020 000099069 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b2 / 141 = 0.014$$c2020$$dQ1$$eT1 000099069 592__ $$a4.336$$b2020 000099069 593__ $$aCardiology and Cardiovascular Medicine$$c2020$$dQ1 000099069 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000099069 700__ $$aMargara, F. 000099069 700__ $$aMarciniak, M. 000099069 700__ $$aRodero, C. 000099069 700__ $$aLoncaric, F. 000099069 700__ $$aFeng, Y. 000099069 700__ $$aGilbert, A. 000099069 700__ $$aFernandes, J.F. 000099069 700__ $$0(orcid)0000-0001-5976-0483$$aBukhari, H.A.$$uUniversidad de Zaragoza 000099069 700__ $$aWajdan, A. 000099069 700__ $$aMartinez, M.V. 000099069 700__ $$aSantos, M.S. 000099069 700__ $$aShamohammdi, M. 000099069 700__ $$aLuo, H. 000099069 700__ $$aWestphal, P. 000099069 700__ $$aLeeson, P. 000099069 700__ $$aDiAchille, P. 000099069 700__ $$aGurev, V. 000099069 700__ $$aMayr, M. 000099069 700__ $$aGeris, L. 000099069 700__ $$aPathmanathan, P. 000099069 700__ $$aMorrison, T. 000099069 700__ $$aCornelussen, R. 000099069 700__ $$aPrinzen, F. 000099069 700__ $$aDelhaas, T. 000099069 700__ $$aDoltra, A. 000099069 700__ $$aSitges, M. 000099069 700__ $$aVigmond, E.J. 000099069 700__ $$aZacur, E. 000099069 700__ $$aGrau, V. 000099069 700__ $$aRodriguez, B. 000099069 700__ $$aRemme, E.W. 000099069 700__ $$aNiederer, S. 000099069 700__ $$aMortier, P. 000099069 700__ $$aMcLeod, K. 000099069 700__ $$aPotse, M. 000099069 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, E.$$uUniversidad de Zaragoza 000099069 700__ $$aBueno-Orovio, A. 000099069 700__ $$aLamata, P. 000099069 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac. 000099069 773__ $$g41, 48 (2020), 4556-4564$$pEur. heart j.$$tEuropean heart journal$$x0195-668X 000099069 8564_ $$s1790208$$uhttps://zaguan.unizar.es/record/99069/files/texto_completo.pdf$$yVersión publicada 000099069 8564_ $$s2646516$$uhttps://zaguan.unizar.es/record/99069/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000099069 909CO $$ooai:zaguan.unizar.es:99069$$particulos$$pdriver 000099069 951__ $$a2023-03-30-09:42:16 000099069 980__ $$aARTICLE