000099076 001__ 99076
000099076 005__ 20230519145518.0
000099076 0247_ $$2doi$$a10.3390/ijms22020583
000099076 0248_ $$2sideral$$a122244
000099076 037__ $$aART-2021-122244
000099076 041__ $$aeng
000099076 100__ $$aPastor, L.
000099076 245__ $$aExtracellular vesicles from airway secretions: New insights in lung diseases
000099076 260__ $$c2021
000099076 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099076 5203_ $$aLung diseases (LD) are one of the most common causes of death worldwide. Although it is known that chronic airway inflammation and excessive tissue repair are processes associated with LD such as asthma, chronic obstructive pulmonary disease (COPD) or idiopathic pulmonary fibro-sis (IPF), their specific pathways remain unclear. Extracellular vesicles (EVs) are heterogeneous na-noscale membrane vesicles with an important role in cell-to-cell communication. EVs are present in general biofluids as plasma or urine but also in secretions of the airway as bronchoalveolar lavage fluid (BALF), induced sputum (IS), nasal lavage (NL) or pharyngeal lavage. Alterations of airway EV cargo could be crucial for understanding LD. Airway EVs have shown a role in the pathogenesis of some LD such as eosinophil increase in asthma, the promotion of lung cancer in vitro models in COPD and as biomarkers to distinguishing IPF in patients with diffuse lung diseases. In addition, they also have a promising future as therapeutics for LD. In this review, we focus on the importance of airway secretions in LD, the pivotal role of EVs from those secretions on their pathophysiology and their potential for biomarker discovery.
000099076 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER-FIS/PI18-01524
000099076 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000099076 590__ $$a6.208$$b2021
000099076 592__ $$a1.176$$b2021
000099076 594__ $$a6.9$$b2021
000099076 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b69 / 297 = 0.232$$c2021$$dQ1$$eT1
000099076 593__ $$aComputer Science Applications$$c2021$$dQ1
000099076 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b50 / 180 = 0.278$$c2021$$dQ2$$eT1
000099076 593__ $$aInorganic Chemistry$$c2021$$dQ1
000099076 593__ $$aSpectroscopy$$c2021$$dQ1
000099076 593__ $$aOrganic Chemistry$$c2021$$dQ1
000099076 593__ $$aPhysical and Theoretical Chemistry$$c2021$$dQ1
000099076 593__ $$aMolecular Biology$$c2021$$dQ1
000099076 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000099076 700__ $$aVera, E.
000099076 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, J.M.$$uUniversidad de Zaragoza
000099076 700__ $$aSanz-Rubio, D.
000099076 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000099076 773__ $$g22, 2 (2021), 583 [21 pp]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000099076 8564_ $$s354535$$uhttps://zaguan.unizar.es/record/99076/files/texto_completo.pdf$$yVersión publicada
000099076 8564_ $$s2730768$$uhttps://zaguan.unizar.es/record/99076/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000099076 909CO $$ooai:zaguan.unizar.es:99076$$particulos$$pdriver
000099076 951__ $$a2023-05-18-15:20:16
000099076 980__ $$aARTICLE