000099087 001__ 99087
000099087 005__ 20210902121941.0
000099087 0247_ $$2doi$$a10.1038/s41598-020-70861-x
000099087 0248_ $$2sideral$$a122329
000099087 037__ $$aART-2020-122329
000099087 041__ $$aeng
000099087 100__ $$aBeltrán-Pavez, C.
000099087 245__ $$aVirological outcome among HIV infected patients transferred from pediatric care to adult units in Madrid, Spain (1997–2017)
000099087 260__ $$c2020
000099087 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099087 5203_ $$aThe aim of this transversal study was to describe the virological and immunological features of HIV-infected youths transferred from pediatric to adult care units since 1997 vs. the non-transferred patients from the Madrid Cohort of HIV-infected children and adolescents in Spain. We included 106 non-transferred and 184 transferred patients under clinical follow-up in 17 public hospitals in Madrid by the end of December 2017. Virological and immunological outcomes were compared in transferred vs. non-transferred patients. ART drug resistance mutations and HIV-variants were analyzed in all subjects with available resistance pol genotypes and/or genotypic resistance profiles. Among the study cohort, 133 (72.3%) of 184 transferred and 75 (70.7%) of 106 non-transferred patients had available resistance genotypes. Most (88.9%) of transferred had ART experience at sampling. A third (33.3%) had had a triple-class experience. Acquired drug resistance (ADR) prevalence was significantly higher in pretreated transferred than non-transferred patients (71.8% vs. 44%; p = 0.0009), mainly to NRTI (72.8% vs. 31.1%; p < 0.0001) and PI (29.1% vs. 12%; p = 0.0262). HIV-1 non-B variants were less frequent in transferred vs. non-transferred (6.9% vs. 32%; p < 0.0001). In conclusion, the frequent resistant genotypes found in transferred youths justifies the reinforcement of HIV resistance monitoring after the transition to avoid future therapeutic failures.
000099087 536__ $$9info:eu-repo/grantAgreement/EUR/ERDF/A way to achieve Europe$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI19-01530$$9info:eu-repo/grantAgreement/ES/ISCIII/PI15-01005-RIS-EPICLIN-02-2016$$9info:eu-repo/grantAgreement/ES/MSCBS/CIBERESP$$9info:eu-repo/grantAgreement/ES/MSCBS-ISCIII-FEDER/RD06-0025$$9info:eu-repo/grantAgreement/ES/MSCBS/RIS-EPICLIN-06-2013$$9info:eu-repo/grantAgreement/ES/MSCBS/RIS-EPICLIN-14-2017
000099087 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000099087 590__ $$a4.379$$b2020
000099087 591__ $$aMULTIDISCIPLINARY SCIENCES$$b17 / 73 = 0.233$$c2020$$dQ1$$eT1
000099087 592__ $$a1.24$$b2020
000099087 593__ $$aMultidisciplinary$$c2020$$dQ1
000099087 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000099087 700__ $$aGutiérrez-López, M.
000099087 700__ $$aRubio-Garrido, M.
000099087 700__ $$aValadés-Alcaraz, A.
000099087 700__ $$aPrieto, L.
000099087 700__ $$aRamos, J.T.
000099087 700__ $$aJiménez De Ory, S.
000099087 700__ $$aNavarro, M.
000099087 700__ $$aDíez-Romero, C.
000099087 700__ $$aPulido, F.
000099087 700__ $$aValencia, E.
000099087 700__ $$aHolguín, Á.
000099087 700__ $$aMellado, M.J.
000099087 700__ $$aEscosa, L.
000099087 700__ $$aGarcía Hortelano, M.
000099087 700__ $$aSainz, T.
000099087 700__ $$aGonzález-Tomé, M.I.
000099087 700__ $$aRojo, P.
000099087 700__ $$aBlázquez, D.
000099087 700__ $$aPrieto-Tato, L.
000099087 700__ $$aEpalza, C.
000099087 700__ $$aRamos, J.T.
000099087 700__ $$aGuillén, S.
000099087 700__ $$aNavarro, M.L.
000099087 700__ $$aSaavedra, J.
000099087 700__ $$aSantos, M.
000099087 700__ $$aSantiago, B.
000099087 700__ $$aAguilera-Alonso, D.
000099087 700__ $$aJiménez De Ory, S.
000099087 700__ $$aCarrasco, I.
000099087 700__ $$aRoa, M.Á.
000099087 700__ $$aPenín, M.
000099087 700__ $$aMartínez, J.
000099087 700__ $$aBadillo, K.
000099087 700__ $$aOñate, E.
000099087 700__ $$aPocheville, I.
000099087 700__ $$aGarrote, E.
000099087 700__ $$aColino, E.
000099087 700__ $$aGómez Sirvent, J.
000099087 700__ $$aGarzón, M.
000099087 700__ $$aRomán, V.
000099087 700__ $$aAngulo, R.
000099087 700__ $$aNeth, O.
000099087 700__ $$aFalcón, L.
000099087 700__ $$aTerol, P.
000099087 700__ $$aSantos, J.L.
000099087 700__ $$aMoreno, D.
000099087 700__ $$aLendínez, F.
000099087 700__ $$aPeromingo, E.
000099087 700__ $$aUberos, J.
000099087 700__ $$aRuiz, B.
000099087 700__ $$aGrande, A.
000099087 700__ $$aRomero, F.J.
000099087 700__ $$aPérez, C.
000099087 700__ $$aLillo, M.
000099087 700__ $$aLosada, B.
000099087 700__ $$aHerranz, M.
000099087 700__ $$aBustillo, M.
000099087 700__ $$0(orcid)0000-0001-8346-0544$$aCollado, P.$$uUniversidad de Zaragoza
000099087 700__ $$aCouceiro, J.A.
000099087 700__ $$aVila, L.
000099087 700__ $$aCalviño, C.
000099087 700__ $$aPiqueras, A.I.
000099087 700__ $$aOltra, M.
000099087 700__ $$aGavilán, C.
000099087 700__ $$aMontesinos, E.
000099087 700__ $$aDapena, M.
000099087 700__ $$aÁlvarez, C.
000099087 700__ $$aJiménez, B.
000099087 700__ $$aAndrés, A.G.
000099087 700__ $$aMarugán, V.
000099087 700__ $$aOchoa, C.
000099087 700__ $$aAlfayate, S.
000099087 700__ $$aMenasalvas, A.I.
000099087 700__ $$aRuiz Del Prado, Y.
000099087 700__ $$aSoler-Palacín, P.
000099087 700__ $$aFrick, M.A.
000099087 700__ $$aMur, A.
000099087 700__ $$aLópez, N.
000099087 700__ $$aMéndez, M.
000099087 700__ $$aMayol, L.
000099087 700__ $$aVallmanya, T.
000099087 700__ $$aCalavia, O.
000099087 700__ $$aGarcía, L.
000099087 700__ $$aColl, M.T.
000099087 700__ $$aPineda, V.
000099087 700__ $$aRius, N.
000099087 700__ $$aDueñas, J.
000099087 700__ $$aFortuny, C.
000099087 700__ $$aNoguera-Julián, A.
000099087 700__ $$aBernardino, I.
000099087 700__ $$aMontes, M.L.
000099087 700__ $$aValencia, E.
000099087 700__ $$aRubio, R.
000099087 700__ $$aPulido, F.
000099087 700__ $$aBisbal, O.
000099087 700__ $$aGaspar Alonso, G.
000099087 700__ $$aBerenguer, J.
000099087 700__ $$aDíez, C.
000099087 700__ $$aAldamiz, T.
000099087 700__ $$aMontilla, P.
000099087 700__ $$aBermúdez, E.
000099087 700__ $$aValerio, M.
000099087 700__ $$aSanz, J.
000099087 700__ $$aArponen, S.
000099087 700__ $$aGimeno, A.
000099087 700__ $$aCervero, M.
000099087 700__ $$aTorres, R.
000099087 700__ $$aMoreno, S.
000099087 700__ $$aPérez, M.ªJ.
000099087 700__ $$aRyan, P.
000099087 700__ $$aTroya, J.
000099087 700__ $$aSanz, J.
000099087 700__ $$aLosa, J.
000099087 700__ $$aGómez, R.
000099087 700__ $$aIribarren, J.A.
000099087 700__ $$aRodríguez, F.
000099087 700__ $$aPascual, L.
000099087 700__ $$aAramburu, M.J.
000099087 700__ $$aGoikoetxea, A.J.
000099087 700__ $$aAguirrebengoa, L.
000099087 700__ $$aMuñoz, J.
000099087 700__ $$aIbarra, S.
000099087 700__ $$aHernández, M.
000099087 700__ $$aGómez Sirvent, J.L.
000099087 700__ $$aRodríguez, J.
000099087 700__ $$aCárdenes, M.Á.
000099087 700__ $$aLópez-Cortés, L.F.
000099087 700__ $$aRoca, C.
000099087 700__ $$aLlaves, S.
000099087 700__ $$aRíos, M.J.
000099087 700__ $$aRodríguez, J.
000099087 700__ $$aPalomo, V.
000099087 700__ $$aPasquau, J.
000099087 700__ $$aGarcía, C.
000099087 700__ $$aHernández, J.
000099087 700__ $$aMartínez, C.
000099087 700__ $$aRivero, A.
000099087 700__ $$aCamacho, Á.
000099087 700__ $$aMerino, D.
000099087 700__ $$aMartínez, E.
000099087 700__ $$aMateos, F.
000099087 700__ $$aBlanch, J.J.
000099087 700__ $$aTorralba, M.
000099087 700__ $$aArazo, P.
000099087 700__ $$aSamperiz, G.
000099087 700__ $$0(orcid)0000-0002-5938-1982$$aCrusells, M.J.$$uUniversidad de Zaragoza
000099087 700__ $$aSan Joaquín, I.
000099087 700__ $$aMiralles, C.
000099087 700__ $$aOcampo, A.
000099087 700__ $$aPousada, G.
000099087 700__ $$aMena, Á.
000099087 700__ $$aMontero, M.
000099087 700__ $$aSalavert, M.
000099087 700__ $$aCuéllar, S.
000099087 700__ $$aGalindo, M.J.
000099087 700__ $$aFerrando, R.
000099087 700__ $$aPortilla, J.
000099087 700__ $$aPortilla, I.
000099087 700__ $$aGutiérrez, F.
000099087 700__ $$aMasiá, M.
000099087 700__ $$aRobledano, C.
000099087 700__ $$aAdsuar, A.
000099087 700__ $$aHinojosa, C.
000099087 700__ $$aBachiller, P.
000099087 700__ $$aAbadía, J.
000099087 700__ $$aMostaza, J.L.
000099087 700__ $$aPérez, R.
000099087 700__ $$aGalera, C.
000099087 700__ $$aAlbendín, H.
000099087 700__ $$aPérez, A.
000099087 700__ $$aBlanco, J.R.
000099087 700__ $$aBurgos, J.
000099087 700__ $$aTorres, B.
000099087 700__ $$aLazzari, E.
000099087 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000099087 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría
000099087 773__ $$g10, 1 (2020), 16891$$pSci. rep.$$tScientific Reports$$x2045-2322
000099087 8564_ $$s409248$$uhttps://zaguan.unizar.es/record/99087/files/texto_completo.pdf$$yVersión publicada
000099087 8564_ $$s2529093$$uhttps://zaguan.unizar.es/record/99087/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
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000099087 951__ $$a2021-09-02-11:01:26
000099087 980__ $$aARTICLE