99092 20210902121600.0 doi 10.1142/S0219519419500647 sideral 113274 ART-2020-113274 eng Urdeitx, Pau Universidad de Zaragoza (orcid)0000-0001-6727-563X Role of oxygen concentration in the osteoblasts behavior: A finite element model 2020 Access copy available to the general public Unrestricted Oxygen concentration plays a key role in cell survival and viability. Besides, it has important effects on essential cellular biological processes such as cell migration, differentiation, proliferation and apoptosis. Therefore, the prediction of the cellular response to the alterations of the oxygen concentration can help significantly in the advances of cell culture research. Here, we present a 3D computational mechanotactic model to simulate all the previously mentioned cell processes under different oxygen concentrations. With this model, three cases have been studied. Starting with mesenchymal stem cells within an extracellular matrix with mechanical properties suitable for its differentiation into osteoblasts, and under different oxygen conditions to evaluate their behavior under normoxia, hypoxia and anoxia. The obtained results, which are consistent with the experimental observations, indicate that cells tend to migrate toward zones with higher oxygen concentration where they accelerate their differentiation and proliferation. This technique can be employed to control cell migration toward fracture zones to accelerate the healing process. Besides, as expected, to avoid cell apoptosis under conditions of anoxia and to avoid the inhibition of the differentiation and proliferation processes under conditions of hypoxia, the state of normoxia should be maintained throughout the entire cell-culture process. info:eu-repo/grantAgreement/ES/DGA/T24-17R info:eu-repo/grantAgreement/ES/ISCIII/CIBER-BBN info:eu-repo/grantAgreement/ES/MINECO/MAT2016-76039-C4-4-R info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 0.897 2020 ENGINEERING, BIOMEDICAL 86 / 90 = 0.956 2020 Q4 T3 BIOPHYSICS 67 / 71 = 0.944 2020 Q4 T3 0.235 2020 Biomedical Engineering 2020 Q4 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Farzaneh, Solmaz Mousavi, S. Jamaleddin (orcid)0000-0003-0509-1450 Doweidar, Mohamed H. Universidad de Zaragoza (orcid)0000-0003-0088-7222 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 19, 5 (2020), 1950064 [24 pp.] Journal of Mechanics in Medicine and Biology Journal of Mechanics in Medicine and Biology 0219-5194 2045359 http://zaguan.unizar.es/record/99092/files/texto_completo.pdf Postprint 1197347 http://zaguan.unizar.es/record/99092/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:99092 articulos driver 2021-09-02-08:34:36 ARTICLE