000099154 001__ 99154
000099154 005__ 20240123082600.0
000099154 0247_ $$2doi$$a10.3390/ani11010146
000099154 0248_ $$2sideral$$a122625
000099154 037__ $$aART-2021-122625
000099154 041__ $$aeng
000099154 100__ $$ade Miguel, R.$$uUniversidad de Zaragoza
000099154 245__ $$aGrowth performance and clinicopathological analyses in lambs repetitively inoculated with aluminum-hydroxide containing vaccines or aluminum-hydroxide only
000099154 260__ $$c2021
000099154 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099154 5203_ $$aAluminum (Al) hydroxide is an effective adjuvant used in sheep vaccines. However, Al-adjuvants have been implicated as potential contributors to a severe wasting syndrome in sheep— the so-called ovine autoimmune-inflammatory syndrome induced by adjuvants (ASIA syndrome). This work aimed to characterize the effects of the repetitive injection of Al-hydroxide containing products in lambs. Four flocks (Flocks 1–4; n = 21 each) kept under different conditions were studied. Three groups of seven lambs (Vaccine, Adjuvant-only, and Control) were established in each flock. Mild differences in average daily gain and fattening index were observed, indicating a reduced growth performance in Vaccine groups, likely related to short-term episodes of pyrexia and decreased daily intake. Clinical and hematological parameters remained within normal limits. Histology showed no significant differences between groups, although there was a tendency to present a higher frequency of hyperchromatic, shrunken neurons in the lumbar spinal cord in the Adjuvant-only group. Although Al-hydroxide was linked to granulomas at the injection site and behavioral changes in sheep, the results of the present experimental work indicate that injected Al-hydroxide is not enough to fully reproduce the wasting presentation of the ASIA syndrome. Other factors such as sex, breed, age, production system, diet or climate conditions could play a role.
000099154 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A17-17R$$9info:eu-repo/grantAgreement/ES/MCIU/RTI2018-096172-B-C31$$9info:eu-repo/grantAgreement/ES/MCIU/RTI2018-096172-B-C33$$9info:eu-repo/grantAgreement/ES/MINECO/AGL2013-49137-C3-1-R$$9info:eu-repo/grantAgreement/ES/MINECO/AGL2013-49137-C3-2-R
000099154 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000099154 590__ $$a3.231$$b2021
000099154 592__ $$a0.61$$b2021
000099154 594__ $$a2.7$$b2021
000099154 591__ $$aVETERINARY SCIENCES$$b16 / 145 = 0.11$$c2021$$dQ1$$eT1
000099154 593__ $$aVeterinary (miscellaneous)$$c2021$$dQ1
000099154 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b13 / 62 = 0.21$$c2021$$dQ1$$eT1
000099154 593__ $$aAnimal Science and Zoology$$c2021$$dQ1
000099154 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000099154 700__ $$aAsín, J.
000099154 700__ $$0(orcid)0000-0002-2685-1730$$aRodríguez-Largo, A.$$uUniversidad de Zaragoza
000099154 700__ $$aEcheverría, I.
000099154 700__ $$0(orcid)0000-0002-7822-6646$$aLacasta, D.$$uUniversidad de Zaragoza
000099154 700__ $$aPinczowski, P.
000099154 700__ $$aGimeno, M.
000099154 700__ $$0(orcid)0000-0001-5050-0167$$aMolín, J.
000099154 700__ $$0(orcid)0000-0002-2557-4890$$aFernández, A.$$uUniversidad de Zaragoza
000099154 700__ $$0(orcid)0000-0002-1204-4356$$ade Blas, I.$$uUniversidad de Zaragoza
000099154 700__ $$ade Andrés, D.
000099154 700__ $$0(orcid)0000-0002-8133-2124$$aPérez, M.$$uUniversidad de Zaragoza
000099154 700__ $$aReina, R.
000099154 700__ $$0(orcid)0000-0002-2053-9842$$aLuján, L.$$uUniversidad de Zaragoza
000099154 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000099154 7102_ $$11001$$2025$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Anatom.Anatom.Patológ.Com
000099154 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000099154 773__ $$g11, 1 (2021), 146 [18 pp]$$pAnimals (Basel)$$tAnimals$$x2076-2615
000099154 8564_ $$s498846$$uhttps://zaguan.unizar.es/record/99154/files/texto_completo.pdf$$yVersión publicada
000099154 8564_ $$s2897901$$uhttps://zaguan.unizar.es/record/99154/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000099154 909CO $$ooai:zaguan.unizar.es:99154$$particulos$$pdriver
000099154 951__ $$a2024-01-23-08:21:58
000099154 980__ $$aARTICLE