99154 20240123082600.0 doi 10.3390/ani11010146 sideral 122625 ART-2021-122625 eng de Miguel, R. Universidad de Zaragoza Growth performance and clinicopathological analyses in lambs repetitively inoculated with aluminum-hydroxide containing vaccines or aluminum-hydroxide only 2021 Access copy available to the general public Unrestricted Aluminum (Al) hydroxide is an effective adjuvant used in sheep vaccines. However, Al-adjuvants have been implicated as potential contributors to a severe wasting syndrome in sheep— the so-called ovine autoimmune-inflammatory syndrome induced by adjuvants (ASIA syndrome). This work aimed to characterize the effects of the repetitive injection of Al-hydroxide containing products in lambs. Four flocks (Flocks 1–4; n = 21 each) kept under different conditions were studied. Three groups of seven lambs (Vaccine, Adjuvant-only, and Control) were established in each flock. Mild differences in average daily gain and fattening index were observed, indicating a reduced growth performance in Vaccine groups, likely related to short-term episodes of pyrexia and decreased daily intake. Clinical and hematological parameters remained within normal limits. Histology showed no significant differences between groups, although there was a tendency to present a higher frequency of hyperchromatic, shrunken neurons in the lumbar spinal cord in the Adjuvant-only group. Although Al-hydroxide was linked to granulomas at the injection site and behavioral changes in sheep, the results of the present experimental work indicate that injected Al-hydroxide is not enough to fully reproduce the wasting presentation of the ASIA syndrome. Other factors such as sex, breed, age, production system, diet or climate conditions could play a role. info:eu-repo/grantAgreement/ES/DGA/A17-17R info:eu-repo/grantAgreement/ES/MCIU/RTI2018-096172-B-C31 info:eu-repo/grantAgreement/ES/MCIU/RTI2018-096172-B-C33 info:eu-repo/grantAgreement/ES/MINECO/AGL2013-49137-C3-1-R info:eu-repo/grantAgreement/ES/MINECO/AGL2013-49137-C3-2-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.231 2021 VETERINARY SCIENCES 16 / 145 = 0.11 2021 Q1 T1 AGRICULTURE, DAIRY & ANIMAL SCIENCE 13 / 62 = 0.21 2021 Q1 T1 0.61 2021 Veterinary (miscellaneous) 2021 Q1 Animal Science and Zoology 2021 Q1 2.7 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Asín, J. Rodríguez-Largo, A. Universidad de Zaragoza (orcid)0000-0002-2685-1730 Echeverría, I. Lacasta, D. Universidad de Zaragoza (orcid)0000-0002-7822-6646 Pinczowski, P. Gimeno, M. Molín, J. (orcid)0000-0001-5050-0167 Fernández, A. Universidad de Zaragoza (orcid)0000-0002-2557-4890 de Blas, I. Universidad de Zaragoza (orcid)0000-0002-1204-4356 de Andrés, D. Pérez, M. Universidad de Zaragoza (orcid)0000-0002-8133-2124 Reina, R. Luján, L. Universidad de Zaragoza (orcid)0000-0002-2053-9842 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 1001 025 Universidad de Zaragoza Dpto. Anatom.,Embri.Genét.Ani. Área Anatom.Anatom.Patológ.Com 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 11, 1 (2021), 146 [18 pp] Animals (Basel) Animals 2076-2615 498846 http://zaguan.unizar.es/record/99154/files/texto_completo.pdf Versión publicada 2897901 http://zaguan.unizar.es/record/99154/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:99154 articulos driver 2024-01-23-08:21:58 ARTICLE