99278 20230519145435.0 doi 10.1371/journal.pone.0245610 sideral 122639 ART-2021-122639 eng Malo, Sara Universidad de Zaragoza (orcid)0000-0002-7194-8275 Effect of patient and treatment factors on persistence with antihypertensive treatment: A population-based study 2021 Access copy available to the general public Unrestricted Purpose: To analyze patterns of antihypertensive drug use among new users in a Southern European population, and identify patient- and treatment-related factors that influence persistence. Methods: This is a retrospective observational study of new antihypertensive drug users aged ≥40 years in Aragón, Spain. Information on antihypertensive drugs (2014-2016) prescribed and dispensed at pharmacies via the public health system were collected from a regional electronic population-based pharmacy database. Persistence was assessed using the gap method. Kaplan-Meier and Cox regression analyses were conducted to analyze patterns of use and factors that influence persistence. Results: The 25,582 new antihypertensive drug users in Aragón during the study period were prescribed antihypertensive drugs in monotherapy (73.3%), fixed combination (13.9%), free combination (9.1%), or other (3.7%). One in five received antihypertensive drugs within 15 days of the prescription date, but not after. During the first year of follow-up, 38.6% of the study population remained persistent. The likelihood of treatment discontinuation was higher for participants who were male, aged ≥80 years, and received an antihypertensive drug in monotherapy compared with fixed combination. Conclusion: Overall persistence with antihypertensive therapy was poor, and was influenced by the sex, age and type of therapy. Fixed combinations appear to be a good choice for initial therapy, especially in patients with a higher risk of discontinuation. Nonetheless, adverse drug effects and the patient's preferences and clinical profile should be taken into account. info:eu-repo/grantAgreement/ES/DGA-GRISSA/B09-17R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.752 2021 MULTIDISCIPLINARY SCIENCES 29 / 74 = 0.392 2021 Q2 T2 0.852 2021 Multidisciplinary 2021 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Aguilar-Palacio, Isabel Universidad de Zaragoza (orcid)0000-0001-7293-701X Feja, Cristina Lallana, MªJesús Armesto, Javier Rabanaque, MªJosé Universidad de Zaragoza (orcid)0000-0002-6671-5661 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 16, 1 (2021), e0245610 [13 pp.] PLoS One PLoS ONE 1932-6203 1149201 http://zaguan.unizar.es/record/99278/files/texto_completo.pdf Versión publicada 2200046 http://zaguan.unizar.es/record/99278/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:99278 articulos driver 2023-05-18-14:23:04 ARTICLE