99331 20210902121706.0 doi 10.1039/d0fo00216j sideral 117795 ART-2020-117795 eng Quero, Javier Insight into the potential application of polyphenol-rich dietary intervention in degenerative disease management 2020 Access copy available to the general public Unrestricted In recent times, a great number of plants have been studied in order to identify new components with nutraceutical properties, among which are polyphenols. Dietary polyphenols represent a large group of bioactive molecules widely found in the food of plant origin and they have been found able to prevent the onset and progression of degenerative diseases, and to reduce and control their symptoms. These health protective effects have been mainly related to their antioxidant and anti-inflammatory properties. However, it must be considered that the application of isolated polyphenols as nutraceuticals is quite limited due to their poor systemic distribution and relative bioavailability. The present review highlights the potential effect of dietary intervention with polyphenol-rich food and plant extracts in patients with cancer, diabetes and neurodegenerative, autoimmune, cardiovascular and ophthalmic diseases, as well as the possible molecular mechanisms of action suggested in numerous studies with animal models. info:eu-repo/grantAgreement/ES/CIBERObn/CB06-03-1012 info:eu-repo/grantAgreement/ES/DGA/B16-R17 info:eu-repo/grantAgreement/ES/DGA/E104 info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-75816-C2-1-P info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/Redvalue-SOE1-PI-E0123 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 5.396 2020 FOOD SCIENCE & TECHNOLOGY 22 / 144 = 0.153 2020 Q1 T1 BIOCHEMISTRY & MOLECULAR BIOLOGY 76 / 297 = 0.256 2020 Q2 T1 1.145 2020 Medicine (miscellaneous) 2020 Q1 Food Science 2020 Q1 info:eu-repo/semantics/review info:eu-repo/semantics/acceptedVersion Mármol, Inés Cerrada, Elena Universidad de Zaragoza (orcid)0000-0003-2457-3674 Rodríguez-Yoldi, María Jesús Universidad de Zaragoza (orcid)0000-0002-3595-7668 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 1005 410 Universidad de Zaragoza Dpto. Farmacología y Fisiolog. Área Fisiología 11, 4 (2020), 2805-2825 FOOD & FUNCTION Food & function 2042-6496 933811 http://zaguan.unizar.es/record/99331/files/texto_completo.pdf Postprint 1228191 http://zaguan.unizar.es/record/99331/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:99331 articulos driver 2021-09-02-09:17:22 ARTICLE