000099360 001__ 99360
000099360 005__ 20210902121633.0
000099360 0247_ $$2doi$$a10.1016/j.colsurfb.2020.110904
000099360 0248_ $$2sideral$$a117159
000099360 037__ $$aART-2020-117159
000099360 041__ $$aeng
000099360 100__ $$0(orcid)0000-0002-6256-742X$$aOrtiz de Solorzano, Isabel
000099360 245__ $$aCustomized hybrid and NIR-light triggered thermoresponsive drug delivery microparticles synthetized by photopolymerization in a one-step flow focusing continuous microreactor
000099360 260__ $$c2020
000099360 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099360 5203_ $$aPhotopolymerization is a selective technique that takes advantage of light-sensitive molecules to initiate and propagate monomeric structures to render covalently bonded macromolecular materials structures known as polymers. Herein, we present a novel one-step microfluidic synthesis of customized hybrid-thermoresponsive Poly(N-isopropylacrylamide) (PNIPAm) based microparticles (MPs) containing plasmonic hollow gold nanoparticles (HGNPs) and bupivacaine (BVP) used as a model drug. Those hybrid microparticles were prepared using a flow-focusing microreactor coupled to a UV LED device built with a simple outer PTFE tubing and an inner flexible capillary. Different tubing characteristics and flow rate ratios were altered in order to control the size of the resulting microparticles. In addition, components such as monomer, crosslinker and photoinitiator concentrations, as well as LED intensity and irradiation time were tuned to obtain different MPs and their characteristics and polymerization rates were compared by Gel Permeation Chromatography (GPC). Thermoresponsive properties were analyzed and the presence of HGNPs was confirmed in light-activated triggered drug release applications. Bupivacaine loading and release studies were evaluated with the resulting hollow and solid microparticles (which were obtained depending on the polymerization rate used) and their temperature responsiveness was assessed using a NIR laser when HGNPs were present in the constructs. Finally, cytotoxicity studies, cell-cycle arrest and apoptotic induction were carried out to certify their suitability for further biomedical applications to be used as triggerable drug depots.
000099360 536__ $$9info:eu-repo/grantAgreement/EC/FP7/614715/EU/A Photo-triggered On-demand Drug Delivery System for Chronic Pain/NANOHEDONISM
000099360 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000099360 590__ $$a5.268$$b2020
000099360 591__ $$aBIOPHYSICS$$b11 / 71 = 0.155$$c2020$$dQ1$$eT1
000099360 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b15 / 40 = 0.375$$c2020$$dQ2$$eT2
000099360 591__ $$aCHEMISTRY, PHYSICAL$$b54 / 162 = 0.333$$c2020$$dQ2$$eT2
000099360 592__ $$a0.938$$b2020
000099360 593__ $$aBiotechnology$$c2020$$dQ1
000099360 593__ $$aColloid and Surface Chemistry$$c2020$$dQ1
000099360 593__ $$aSurfaces and Interfaces$$c2020$$dQ1
000099360 593__ $$aPhysical and Theoretical Chemistry$$c2020$$dQ1
000099360 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000099360 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000099360 700__ $$0(orcid)0000-0003-2293-363X$$aMendoza, Gracia$$uUniversidad de Zaragoza
000099360 700__ $$0(orcid)0000-0003-3165-0156$$aArruebo, Manuel$$uUniversidad de Zaragoza
000099360 700__ $$0(orcid)0000-0002-6873-5244$$aSebastian, Víctor$$uUniversidad de Zaragoza
000099360 7102_ $$15005$$2555$$aUniversidad de Zaragoza$$bDpto. Ing.Quím.Tecnol.Med.Amb.$$cÁrea Ingeniería Química
000099360 773__ $$g190 (2020), 110904 1-11$$pColloids surf., B Biointerfaces$$tCOLLOIDS AND SURFACES B-BIOINTERFACES$$x0927-7765
000099360 8564_ $$s554801$$uhttps://zaguan.unizar.es/record/99360/files/texto_completo.pdf$$yPostprint
000099360 8564_ $$s980404$$uhttps://zaguan.unizar.es/record/99360/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000099360 909CO $$ooai:zaguan.unizar.es:99360$$particulos$$pdriver
000099360 951__ $$a2021-09-02-08:54:46
000099360 980__ $$aARTICLE