Human-based approaches to pharmacology and cardiology: an interdisciplinary and intersectorial workshop
Rodriguez, Blanca ; Carusi, Annamaria ; Abi-Gerges, Najah ; Ariga, Rina ; Britton, Oliver ; Bub, Gil ; Bueno-Orovio, Alfonso ; Burton, Rebecca A. B. ; Carapella, Valentina ; Cardone-Noott, Louie ; Daniels, Matthew J. ; Davies, Mark R. ; Dutta, Sara ; Ghetti, Andre ; Grau, Vicente ; Harmer, Stephen ; Kopljar, Ivan ; Lambiase, Pier ; Rong Lu, Hua ; Lyon, Aurore ; Minchole, Ana ; Muszkiewicz, Anna ; Oster, Julien ; Paci, Michelangelo ; Passini, Elisa ; Severi, Stefano ; Taggart, Peter ; Tinker, Andy ; Valentin, Jean-Pierre ; Varro, Andras ; Wallman, Mikael ; Zhou, Xin
Resumen: Both biomedical research and clinical practice rely on complex datasets for the physiological and genetic characterization of human hearts in
health and disease. Given the complexity and variety of approaches and recordings, there is now growing recognition of the need to embed
computational methods in cardiovascular medicine and science for analysis, integration and prediction. This paper describes a Workshop on
Computational Cardiovascular Science that created an international, interdisciplinary and inter-sectorial forum to define the next steps for a
human-based approach to disease supported by computational methodologies. The main ideas highlighted were (i) a shift towards humanbased
methodologies, spurred by advances in new in silico, in vivo, in vitro, and ex vivo techniques and the increasing acknowledgement of the
limitations of animal models. (ii) Computational approaches complement, expand, bridge, and integrate in vitro, in vivo, and ex vivo experimental
and clinical data and methods, and as such they are an integral part of human-based methodologies in pharmacology and medicine. (iii) The
effective implementation of multi- and interdisciplinary approaches, teams, and training combining and integrating computational methods with
experimental and clinical approaches across academia, industry, and healthcare settings is a priority. (iv) The human-based cross-disciplinary
approach requires experts in specific methodologies and domains, who also have the capacity to communicate and collaborate across disciplines
and cross-sector environments. (v) This new translational domain for human-based cardiology and pharmacology requires new partnerships
supported financially and institutionally across sectors. Institutional, organizational, and social barriers must be identified, understood and
overcome in each specific setting.
Idioma: Inglés
DOI: 10.1093/europace/euv320
Año: 2015
Publicado en: Europace 18, 9 (2015), 1287 - 1298
ISSN: 1099-5129
Factor impacto JCR: 4.021 (2015)
Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 32 / 124 = 0.258 (2015) - Q2 - T1
Factor impacto SCIMAGO: 2.412 - Physiology (medical) (Q1) - Cardiology and Cardiovascular Medicine (Q1)
Tipo y forma: Artículo (Versión definitiva)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace.
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health and disease. Given the complexity and variety of approaches and recordings, there is now growing recognition of the need to embed
computational methods in cardiovascular medicine and science for analysis, integration and prediction. This paper describes a Workshop on
Computational Cardiovascular Science that created an international, interdisciplinary and inter-sectorial forum to define the next steps for a
human-based approach to disease supported by computational methodologies. The main ideas highlighted were (i) a shift towards humanbased
methodologies, spurred by advances in new in silico, in vivo, in vitro, and ex vivo techniques and the increasing acknowledgement of the
limitations of animal models. (ii) Computational approaches complement, expand, bridge, and integrate in vitro, in vivo, and ex vivo experimental
and clinical data and methods, and as such they are an integral part of human-based methodologies in pharmacology and medicine. (iii) The
effective implementation of multi- and interdisciplinary approaches, teams, and training combining and integrating computational methods with
experimental and clinical approaches across academia, industry, and healthcare settings is a priority. (iv) The human-based cross-disciplinary
approach requires experts in specific methodologies and domains, who also have the capacity to communicate and collaborate across disciplines
and cross-sector environments. (v) This new translational domain for human-based cardiology and pharmacology requires new partnerships
supported financially and institutionally across sectors. Institutional, organizational, and social barriers must be identified, understood and
overcome in each specific setting.
Idioma: Inglés
DOI: 10.1093/europace/euv320
Año: 2015
Publicado en: Europace 18, 9 (2015), 1287 - 1298
ISSN: 1099-5129
Factor impacto JCR: 4.021 (2015)
Categ. JCR: CARDIAC & CARDIOVASCULAR SYSTEMS rank: 32 / 124 = 0.258 (2015) - Q2 - T1
Factor impacto SCIMAGO: 2.412 - Physiology (medical) (Q1) - Cardiology and Cardiovascular Medicine (Q1)
Tipo y forma: Artículo (Versión definitiva)
Debe reconocer adecuadamente la autoría, proporcionar un enlace a la licencia e indicar si se han realizado cambios. Puede hacerlo de cualquier manera razonable, pero no de una manera que sugiera que tiene el apoyo del licenciador o lo recibe por el uso que hace. Exportado de SIDERAL (2024-09-12-13:15:37)
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