000099385 001__ 99385
000099385 005__ 20210226222256.0
000099385 0247_ $$2doi$$a10.1093/schbul/sby113
000099385 0248_ $$2sideral$$a123063
000099385 037__ $$aART-2019-123063
000099385 041__ $$aeng
000099385 100__ $$aNúñez, C.
000099385 245__ $$aNeutrophil count is associated with reduced gray matter and enlarged ventricles in first-episode psychosis
000099385 260__ $$c2019
000099385 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099385 5203_ $$aAlthough there is recent evidence that cells from the peripheral immune system can gain access to the central nervous system in certain conditions such as multiple sclerosis, their role has not been assessed in psychosis. Here, we aimed to explore whether blood cell count was associated with brain volume and/or clinical symptomatology. A total of 218 participants (137 first-episode psychosis patients [FEP] and 81 healthy controls [HC]) were included in the study. For each participant, a T1 structural image was acquired, from which brain tissue volumes were calculated. We found that, in FEP, neutrophil count was associated with reduced gray matter (GM) volume (ß = -0.117, P < .001) and increased cerebrospinal fluid volume (ß = 0.191, P = .007). No associations were observed in HC. GM reduction was generalized but more prominent in certain regions, notably the thalamus, the anterior insula, and the left Heschl''s gyrus, among many others. Neutrophil count was also associated with the total PANSS score (ß = 0.173, P = .038), including those items assessing hallucinations (ß = 0.182, P = .028) and avolition (ß = 0.197, P = .018). Several confounders, such as antipsychotic medication, body mass index, and smoking, were controlled for. Overall, the present study may represent the first indirect evidence of brain tissue loss associated with neutrophils in psychosis, and lends support to the hypothesis of a dysregulated immune system. Higher neutrophil count was also associated with more severe clinical symptomatology, which renders it a promising indicator of schizophrenia severity and could even give rise to new therapies.
000099385 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/Una manera de hacer Europa$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/PI-080208-PEPs study$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/CIBERSAM
000099385 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000099385 590__ $$a7.958$$b2019
000099385 591__ $$aPSYCHIATRY$$b6 / 140 = 0.043$$c2019$$dQ1$$eT1
000099385 591__ $$aPSYCHIATRY$$b9 / 154 = 0.058$$c2019$$dQ1$$eT1
000099385 592__ $$a3.604$$b2019
000099385 593__ $$aPsychiatry and Mental Health$$c2019$$dQ1
000099385 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000099385 700__ $$aStephan-Otto, C.
000099385 700__ $$aUsall, J.
000099385 700__ $$aBioque, M.
000099385 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, A.$$uUniversidad de Zaragoza
000099385 700__ $$aGonzález-Pinto, A.
000099385 700__ $$aPina-Camacho, L.
000099385 700__ $$aVieta, E.
000099385 700__ $$aCastro-Fornieles, J.
000099385 700__ $$aRodriguez-Jimenez, R.
000099385 700__ $$aButjosa, A.
000099385 700__ $$aJanssen, J.
000099385 700__ $$aCabrera, B.
000099385 700__ $$aParellada, M.
000099385 700__ $$aBernardo, M.
000099385 700__ $$aMezquida, G.
000099385 700__ $$aAmoretti, S.
000099385 700__ $$aRodríguez-Toscano, E.
000099385 700__ $$aAlemán, Y.
000099385 700__ $$aZorrilla, I.
000099385 700__ $$aGarcía, S.
000099385 700__ $$aDe-La-Cámara, C.
000099385 700__ $$aBarcones, F.
000099385 700__ $$aSanjuan, J.
000099385 700__ $$aEscartí, M.J.
000099385 700__ $$aMané, A.
000099385 700__ $$aCáceres, I.
000099385 700__ $$aTomioka, Y.
000099385 700__ $$aSánchez-Moreno, J.
000099385 700__ $$aDe La Serna, E.
000099385 700__ $$aBaeza, I.
000099385 700__ $$aContreras, F.
000099385 700__ $$aAlbacete, À.
000099385 700__ $$aMorales-Muñoz, I.
000099385 700__ $$aDompablo, M.
000099385 700__ $$aDolz, M.
000099385 700__ $$aRubio-Abadal, E.
000099385 700__ $$aPomarol-Clotet, E.
000099385 700__ $$aSarró, S.
000099385 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000099385 773__ $$g45, 4 (2019), 846-858$$pSchizophr. bull.$$tSchizophrenia bulletin$$x0586-7614
000099385 8564_ $$s327968$$uhttps://zaguan.unizar.es/record/99385/files/texto_completo.pdf$$yPostprint
000099385 8564_ $$s3280560$$uhttps://zaguan.unizar.es/record/99385/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000099385 909CO $$ooai:zaguan.unizar.es:99385$$particulos$$pdriver
000099385 951__ $$a2021-02-26-20:03:45
000099385 980__ $$aARTICLE