000099441 001__ 99441
000099441 005__ 20210302143912.0
000099441 0247_ $$2doi$$a10.3389/fphys.2019.01103
000099441 0248_ $$2sideral$$a122802
000099441 037__ $$aART-2019-122802
000099441 041__ $$aeng
000099441 100__ $$aMincholé, Ana$$uUniversidad de Zaragoza
000099441 245__ $$aMRI-Based Computational Torso/Biventricular Multiscale Models to Investigate the Impact of Anatomical Variability on the ECG QRS Complex
000099441 260__ $$c2019
000099441 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099441 5203_ $$aAims:Patient-to-patient anatomical differences are an important source of variability in the electrocardiogram, and they may compromise the identification of pathological electrophysiological abnormalities. This study aims at quantifying the contribution of variability in ventricular and torso anatomies to differences in QRS complexes of the 12-lead ECG using computer simulations.
Methods:A computational pipeline is presented that enables computer simulations using human torso/biventricular anatomically based electrophysiological models from clinically standard magnetic resonance imaging (MRI). The ventricular model includes membrane kinetics represented by the biophysically detailed O’Hara Rudy model modified for tissue heterogeneity and includes fiber orientation based on the Streeter rule. A population of 265 torso/biventricular models was generated by combining ventricular and torso anatomies obtained from clinically standard MRIs, augmented with a statistical shape model of the body. 12-lead ECGs were simulated on the 265 human torso/biventricular electrophysiology models, and QRS morphology,duration and amplitude were quantified in each ECG lead for each of the human torso-biventricular models.
Results:QRS morphologies in limb leads are mainly determined by ventricular anatomy,while in the precordial leads, and especially V1 to V4, they are determined by heart position within the torso. Differences in ventricular orientation within the torso can explain morphological variability from monophasic to biphasic QRS complexes. QRS duration ismainly influenced by myocardial volume, while it is hardly affected by the torso anatomyor position. An average increase of 0.12±0.05 ms in QRS duration is obtained for eachcm3of myocardial volume across all the leads while it hardly changed due to changes in torso volume.
Conclusion:Computer simulations using populations of human torso/biventricular models based on clinical MRI enable quantification of anatomical causes of variability in the QRS complex of the 12-lead ECG. The human models presented also pave theway toward their use as testbeds in silico clinical trials
000099441 536__ $$9info:eu-repo/grantAgreement/EC/H2020/675451/EU/A Centre of Excellence in Computational Biomedicine/CompBioMed$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 675451-CompBioMed
000099441 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000099441 590__ $$a3.367$$b2019
000099441 591__ $$aPHYSIOLOGY$$b20 / 81 = 0.247$$c2019$$dQ1$$eT1
000099441 592__ $$a1.211$$b2019
000099441 593__ $$aPhysiology (medical)$$c2019$$dQ2
000099441 593__ $$aPhysiology$$c2019$$dQ2
000099441 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000099441 700__ $$aZacur, Ernesto
000099441 700__ $$aAriga, Rina
000099441 700__ $$aGrau, Vicente
000099441 700__ $$aRodriguez, Blanca
000099441 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000099441 773__ $$g10, 1103 (2019), 1 - 16$$pFront. physiol.$$tFRONTIERS IN PHYSIOLOGY$$x1664-042X
000099441 8564_ $$s5341820$$uhttps://zaguan.unizar.es/record/99441/files/texto_completo.pdf$$yVersión publicada
000099441 8564_ $$s2173684$$uhttps://zaguan.unizar.es/record/99441/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000099441 909CO $$ooai:zaguan.unizar.es:99441$$particulos$$pdriver
000099441 951__ $$a2021-03-02-12:36:39
000099441 980__ $$aARTICLE