doi:10.3390/diagnostics11010136engOrduna-Hospital, E.Otero-Rodriguez, J.Perdices, L.Sanchez-Cano, A.Boned-Murillo, A.Acha, J.Pinilla, I.Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without RetinopathyART-2021-122871Background: We aimed to measure and correlate inner retinal layer (IRL) thickness and macular sensitivity by optical coherence tomography (OCT) and by microperimetry, respectively, in type 1 diabetes mellitus patients (DM1) without diabetic retinopathy (DR). Methods: Fifty-one DM1 patients and 81 age-matched healthy subjects underwent measurement of the axial length (AL), retinal thickness in the macular ETDRS areas by swept source (SS)-OCT and macular sensitivity by microperimeter. Results: The total retinal and IRL thicknesses were thicker in the DM1 group (p < 0.05) in practically all ETDRS areas, and they had a generalized decrease in sensitivity (p < 0.05) in 9 areas between both groups. There was a significant negative correlation between retinal sensitivity and age in all areas and in visual acuity (VA) in 5 out of the 9 areas for DM1 patients. Only a mild negative correlation was observed between retinal sensitivity in the 5 degrees nasal inner (5NI) area and in IRL thickness in the temporal inner (TI) area (-0.309 with p = 0.029) in the DM1 group. Conclusion: Aging and disease evolution in DM1 patients without DR signs generate a decrease in retinal sensitivity. There was a direct relationship between retinal sensitivity and macular thickness in the DM1 group.2021http://zaguan.unizar.es/record/9967610.3390/diagnostics11010136http://zaguan.unizar.es/record/99676oai:zaguan.unizar.es:99676info:eu-repo/grantAgreement/ES/DGA/B08-7Rinfo:eu-repo/grantAgreement/ES/ISCIII-MINECO/RD16-0008info:eu-repo/grantAgreement/ES/ISCIII/PI13-01124Diagnostics 11, 1 (2021), 136 [12 pp.]byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess