99676 20230519145515.0 doi 10.3390/diagnostics11010136 sideral 122871 ART-2021-122871 eng Orduna-Hospital, E. Universidad de Zaragoza (orcid)0000-0003-2710-1875 Microperimetry and Optical Coherence Tomography Changes in Type-1 Diabetes Mellitus without Retinopathy 2021 Access copy available to the general public Unrestricted Background: We aimed to measure and correlate inner retinal layer (IRL) thickness and macular sensitivity by optical coherence tomography (OCT) and by microperimetry, respectively, in type 1 diabetes mellitus patients (DM1) without diabetic retinopathy (DR). Methods: Fifty-one DM1 patients and 81 age-matched healthy subjects underwent measurement of the axial length (AL), retinal thickness in the macular ETDRS areas by swept source (SS)-OCT and macular sensitivity by microperimeter. Results: The total retinal and IRL thicknesses were thicker in the DM1 group (p < 0.05) in practically all ETDRS areas, and they had a generalized decrease in sensitivity (p < 0.05) in 9 areas between both groups. There was a significant negative correlation between retinal sensitivity and age in all areas and in visual acuity (VA) in 5 out of the 9 areas for DM1 patients. Only a mild negative correlation was observed between retinal sensitivity in the 5 degrees nasal inner (5NI) area and in IRL thickness in the temporal inner (TI) area (-0.309 with p = 0.029) in the DM1 group. Conclusion: Aging and disease evolution in DM1 patients without DR signs generate a decrease in retinal sensitivity. There was a direct relationship between retinal sensitivity and macular thickness in the DM1 group. info:eu-repo/grantAgreement/ES/DGA/B08-7R info:eu-repo/grantAgreement/ES/ISCIII-MINECO/RD16-0008 info:eu-repo/grantAgreement/ES/ISCIII/PI13-01124 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.992 2021 MEDICINE, GENERAL & INTERNAL 60 / 172 = 0.349 2021 Q2 T2 0.658 2021 Clinical Biochemistry 2021 Q2 2.4 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Otero-Rodriguez, J. Perdices, L. (orcid)0000-0002-9261-0302 Sanchez-Cano, A. Universidad de Zaragoza (orcid)0000-0002-5621-1937 Boned-Murillo, A. Acha, J. Universidad de Zaragoza (orcid)0000-0002-2987-6351 Pinilla, I. Universidad de Zaragoza (orcid)0000-0003-0349-9997 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1013 646 Universidad de Zaragoza Dpto. Cirugía Área Oftalmología 2002 647 Universidad de Zaragoza Dpto. Física Aplicada Área Óptica 11, 1 (2021), 136 [12 pp.] Diagnostics 2075-4418 6898682 http://zaguan.unizar.es/record/99676/files/texto_completo.pdf Versión publicada 2753612 http://zaguan.unizar.es/record/99676/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:99676 articulos driver 2023-05-18-15:15:41 ARTICLE