000099688 001__ 99688
000099688 005__ 20230519145418.0
000099688 0247_ $$2doi$$a10.1038/s41598-021-82502-y
000099688 0248_ $$2sideral$$a123127
000099688 037__ $$aART-2021-123127
000099688 041__ $$aeng
000099688 100__ $$aAshrafi, M.
000099688 245__ $$aOn the effect of antiresorptive drugs on the bone remodeling of the mandible after dental implantation: a mathematical model
000099688 260__ $$c2021
000099688 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099688 5203_ $$aBone remodeling identifies the process of permanent bone change with new bone formation and old bone resorption. Understanding this process is essential in many applications, such as optimizing the treatment of diseases like osteoporosis, maintaining bone density in long-term periods of disuse, or assessing the long-term evolution of the bone surrounding prostheses after implantation. A particular case of study is the bone remodeling process after dental implantation. Despite the overall success of this type of implants, the increasing life expectancy in developed countries has boosted the demand for dental implants in patients with osteoporosis. Although several studies demonstrate a high success rate of dental implants in osteoporotic patients, it is also known that the healing time and the failure rate increase, necessitating the adoption of pharmacological measures to improve bone quality in those patients. However, the general efficacy of these antiresorptive drugs for osteoporotic patients is still controversial, requiring more experimental and clinical studies. In this work, we investigate the effect of different doses of several drugs, used nowadays in osteoporotic patients, on the evolution of bone density after dental implantation. With this aim, we use a pharmacokinetic–pharmacodynamic (PK/PD) mathematical model that includes the effect of antiresorptive drugs on the RANK/RANK-L/OPG pathway, as well as the mechano-chemical coupling with external mechanical loads. This mechano-PK/PD model is then used to analyze the evolution of bone in normal and osteoporotic mandibles after dental implantation with different drug dosages. We show that using antiresorptive agents such as bisphosphonates or denosumab increases bone density and the associated mechanical properties, but at the same time, it also increases bone brittleness. We conclude that, despite the many limitations of these very complex models, the one presented here is capable of predicting qualitatively the evolution of some of the main biological and chemical variables associated with the process of bone remodeling in patients receiving drugs for osteoporosis, so it could be used to optimize dental implant design and coating for osteoporotic patients, as well as the drug dosage protocol for patient-specific treatments.
000099688 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000099688 590__ $$a4.997$$b2021
000099688 592__ $$a1.005$$b2021
000099688 591__ $$aMULTIDISCIPLINARY SCIENCES$$b19 / 74 = 0.257$$c2021$$dQ2$$eT1
000099688 593__ $$aMultidisciplinary$$c2021$$dQ1
000099688 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000099688 700__ $$aGhalichi, F.
000099688 700__ $$aMirzakouchaki, B.
000099688 700__ $$0(orcid)0000-0001-8741-6452$$aDoblare, M.$$uUniversidad de Zaragoza
000099688 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000099688 773__ $$g11, 1 (2021), 2792 [20 pp]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000099688 8564_ $$s2835470$$uhttps://zaguan.unizar.es/record/99688/files/texto_completo.pdf$$yVersión publicada
000099688 8564_ $$s2490688$$uhttps://zaguan.unizar.es/record/99688/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000099688 909CO $$ooai:zaguan.unizar.es:99688$$particulos$$pdriver
000099688 951__ $$a2023-05-18-14:04:27
000099688 980__ $$aARTICLE