000099690 001__ 99690
000099690 005__ 20240209144726.0
000099690 0247_ $$2doi$$a10.1038/s41598-021-82935-5
000099690 0248_ $$2sideral$$a123129
000099690 037__ $$aART-2021-123129
000099690 041__ $$aeng
000099690 100__ $$aPalmieri, F.
000099690 245__ $$aMonitoring blood potassium concentration in hemodialysis patients by quantifying T-wave morphology dynamics
000099690 260__ $$c2021
000099690 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099690 5203_ $$aWe investigated the ability of time-warping-based ECG-derived markers of T-wave morphology changes in time (dw) and amplitude (da), as well as their non-linear components (dNLw and dNLa), and the heart rate corrected counterpart (dw,c), to monitor potassium concentration ([K+]) changes (Δ[K+]) in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). We compared the performance of the proposed time-warping markers, together with other previously proposed [K+] markers, such as T-wave width (Tw) and T-wave slope-to-amplitude ratio (TS/A), when computed from standard ECG leads as well as from principal component analysis (PCA)-based leads. 48-hour ECG recordings and a set of hourly-collected blood samples from 29 ESRD-HD patients were acquired. Values of dw, da, dNLw, dNLa and dw,c were calculated by comparing the morphology of the mean warped T-waves (MWTWs) derived at each hour along the HD with that from a reference MWTW, measured at the end of the HD. From the same MWTWs Tw and TS/A were also extracted. Similarly, Δ[K+] was calculated as the difference between the [K+] values at each hour and the [K+] reference level at the end of the HD session. We found that dw and dw,c showed higher correlation coefficients with Δ[K+] than TS/A—Spearman’s (ρ) and Pearson’s (r)—and Tw—Spearman’s (ρ)—in both SL and PCA approaches being the intra-patient median ρ≥0.82 and r≥0.87 in SL and ρ≥0.82 and r≥0.89 in PCA respectively. Our findings would point at dw and dw,c as the most suitable surrogate of Δ[K+], suggesting that they could be potentially useful for non-invasive monitoring of ESRD-HD patients in hospital, as well as in ambulatory settings. Therefore, the tracking of T-wave morphology variations by means of time-warping analysis could improve continuous and remote [K+] monitoring of ESRD-HD patients and flagging risk of [K+]-related cardiovascular events.
000099690 536__ $$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-105674RB-I00$$9info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-104881RB-I00$$9info:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284$$9info:eu-repo/grantAgreement/ES/DGA/LMP124-18$$9info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group$$9info:eu-repo/grantAgreement/ES/DGA-FSE/Building Europe from Aragon$$9info:eu-repo/grantAgreement/ES/CIBER-BBN/DEKOALE
000099690 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000099690 590__ $$a4.997$$b2021
000099690 592__ $$a1.005$$b2021
000099690 591__ $$aMULTIDISCIPLINARY SCIENCES$$b19 / 74 = 0.257$$c2021$$dQ2$$eT1
000099690 593__ $$aMultidisciplinary$$c2021$$dQ1
000099690 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000099690 700__ $$aGomis, P.
000099690 700__ $$aFerreira, D.
000099690 700__ $$0(orcid)0000-0002-4351-8518$$aRuiz, J.E.$$uUniversidad de Zaragoza
000099690 700__ $$aBergasa, B.
000099690 700__ $$0(orcid)0000-0003-0226-4950$$aMartín-Yebra, A.
000099690 700__ $$0(orcid)0000-0001-5976-0483$$aBukhari, H.A.$$uUniversidad de Zaragoza
000099690 700__ $$0(orcid)0000-0002-1960-407X$$aPueyo, E.$$uUniversidad de Zaragoza
000099690 700__ $$0(orcid)0000-0002-7503-3339$$aMartínez, J.P.$$uUniversidad de Zaragoza
000099690 700__ $$aRamírez, J.
000099690 700__ $$0(orcid)0000-0003-3434-9254$$aLaguna, P.$$uUniversidad de Zaragoza
000099690 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000099690 7102_ $$15008$$2800$$aUniversidad de Zaragoza$$bDpto. Ingeniería Electrón.Com.$$cÁrea Teoría Señal y Comunicac.
000099690 773__ $$g11, 1 (2021), 3883 [15 pp]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000099690 8564_ $$s1584206$$uhttps://zaguan.unizar.es/record/99690/files/texto_completo.pdf$$yVersión publicada
000099690 8564_ $$s2583796$$uhttps://zaguan.unizar.es/record/99690/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000099690 909CO $$ooai:zaguan.unizar.es:99690$$particulos$$pdriver
000099690 951__ $$a2024-02-09-14:45:14
000099690 980__ $$aARTICLE