99690 20240209144726.0 doi 10.1038/s41598-021-82935-5 sideral 123129 ART-2021-123129 eng Palmieri, F. Monitoring blood potassium concentration in hemodialysis patients by quantifying T-wave morphology dynamics 2021 Access copy available to the general public Unrestricted We investigated the ability of time-warping-based ECG-derived markers of T-wave morphology changes in time (dw) and amplitude (da), as well as their non-linear components (dNLw and dNLa), and the heart rate corrected counterpart (dw,c), to monitor potassium concentration ([K+]) changes (Δ[K+]) in end-stage renal disease (ESRD) patients undergoing hemodialysis (HD). We compared the performance of the proposed time-warping markers, together with other previously proposed [K+] markers, such as T-wave width (Tw) and T-wave slope-to-amplitude ratio (TS/A), when computed from standard ECG leads as well as from principal component analysis (PCA)-based leads. 48-hour ECG recordings and a set of hourly-collected blood samples from 29 ESRD-HD patients were acquired. Values of dw, da, dNLw, dNLa and dw,c were calculated by comparing the morphology of the mean warped T-waves (MWTWs) derived at each hour along the HD with that from a reference MWTW, measured at the end of the HD. From the same MWTWs Tw and TS/A were also extracted. Similarly, Δ[K+] was calculated as the difference between the [K+] values at each hour and the [K+] reference level at the end of the HD session. We found that dw and dw,c showed higher correlation coefficients with Δ[K+] than TS/A—Spearman’s (ρ) and Pearson’s (r)—and Tw—Spearman’s (ρ)—in both SL and PCA approaches being the intra-patient median ρ≥0.82 and r≥0.87 in SL and ρ≥0.82 and r≥0.89 in PCA respectively. Our findings would point at dw and dw,c as the most suitable surrogate of Δ[K+], suggesting that they could be potentially useful for non-invasive monitoring of ESRD-HD patients in hospital, as well as in ambulatory settings. Therefore, the tracking of T-wave morphology variations by means of time-warping analysis could improve continuous and remote [K+] monitoring of ESRD-HD patients and flagging risk of [K+]-related cardiovascular events. info:eu-repo/grantAgreement/ES/CIBER-BBN/DEKOALE info:eu-repo/grantAgreement/ES/DGA-FSE/Building Europe from Aragon info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group info:eu-repo/grantAgreement/ES/DGA/LMP124-18 info:eu-repo/grantAgreement/EUR/ERC-2014-StG-638284 info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-104881RB-I00 info:eu-repo/grantAgreement/ES/MICINN-FEDER/PID2019-105674RB-I00 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.997 2021 MULTIDISCIPLINARY SCIENCES 19 / 74 = 0.257 2021 Q2 T1 1.005 2021 Multidisciplinary 2021 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Gomis, P. Ferreira, D. Ruiz, J.E. Universidad de Zaragoza (orcid)0000-0002-4351-8518 Bergasa, B. Martín-Yebra, A. (orcid)0000-0003-0226-4950 Bukhari, H.A. Universidad de Zaragoza (orcid)0000-0001-5976-0483 Pueyo, E. Universidad de Zaragoza (orcid)0000-0002-1960-407X Martínez, J.P. Universidad de Zaragoza (orcid)0000-0002-7503-3339 Ramírez, J. Laguna, P. Universidad de Zaragoza (orcid)0000-0003-3434-9254 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 11, 1 (2021), 3883 [15 pp] Sci. rep. (Nat. Publ. Group) Scientific reports (Nature Publishing Group) 2045-2322 1584206 http://zaguan.unizar.es/record/99690/files/texto_completo.pdf Versión publicada 2583796 http://zaguan.unizar.es/record/99690/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:99690 articulos driver 2024-02-09-14:45:14 ARTICLE