000099707 001__ 99707
000099707 005__ 20230519145501.0
000099707 0247_ $$2doi$$a10.3390/ijerph18041370
000099707 0248_ $$2sideral$$a123206
000099707 037__ $$aART-2021-123206
000099707 041__ $$aeng
000099707 100__ $$aVaquero-Puyuelo, D.
000099707 245__ $$aAnhedonia as a potential risk factor of alzheimer’s disease in a community-dwelling elderly sample: Results from the zarademp project
000099707 260__ $$c2021
000099707 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099707 5203_ $$a(1) Introduction: Dementia is a major public health problem, and Alzheimer’s disease (AD) is the most frequent subtype. Clarifying the potential risk factors is necessary in order to improve dementia-prevention strategies and quality of life. Here, our purpose was to investigate the role of the absence of hedonic tone; anhedonia, understood as the reduction on previous enjoyable daily activities, which occasionally is underdetected and underdiagnosed; and the risk of developing AD in a cognitively unimpaired and non-depressed population sample.
(2) Method: We used data from the Zaragoza Dementia and Depression (ZARADEMP) project, a longitudinal epidemiological study on dementia and depression. After excluding subjects with dementia, a sample of 2830 dwellers aged =65 years was followed for 4.5 years. The geriatric mental state examination was used to identify cases of anhedonia. AD was diagnosed by a panel of research psychiatrists according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria. A multivariate survival analysis and Cox proportional hazards regression model were performed, and the analysis was controlled by an analysis for the presence of clinically significant depression.
(3) Results: We found a significant association between anhedonia cases and AD risk in the univariate analysis (hazard ratio (HR): 2.37; 95% CI: 1.04–5.40). This association persisted more strongly in the fully adjusted model.
(4) Conclusions: Identifying cognitively intact individuals with anhedonia is a priority to implement preventive strategies that could delay the progression of cognitive and functional impairment in subjects at risk of AD.
000099707 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B15-17R$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/PI16-00896$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Una manera de hacer Europa$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/PI-19-01874$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103
000099707 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000099707 590__ $$a4.614$$b2021
000099707 592__ $$a0.814$$b2021
000099707 594__ $$a4.5$$b2021
000099707 591__ $$aPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH$$b45 / 183 = 0.246$$c2021$$dQ1$$eT1
000099707 593__ $$aPollution$$c2021$$dQ1
000099707 591__ $$aPUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH$$b71 / 210 = 0.338$$c2021$$dQ2$$eT2
000099707 593__ $$aHealth, Toxicology and Mutagenesis$$c2021$$dQ1
000099707 591__ $$aENVIRONMENTAL SCIENCES$$b100 / 279 = 0.358$$c2021$$dQ2$$eT2
000099707 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000099707 700__ $$0(orcid)0000-0003-2284-7862$$aDe-La-Cámara, C.$$uUniversidad de Zaragoza
000099707 700__ $$aOlaya, B.
000099707 700__ $$0(orcid)0000-0001-9822-6312$$aGracia-García, P.$$uUniversidad de Zaragoza
000099707 700__ $$0(orcid)0000-0002-9098-655X$$aLobo, A.$$uUniversidad de Zaragoza
000099707 700__ $$0(orcid)0000-0002-3360-7015$$aLópez-Antón, R.$$uUniversidad de Zaragoza
000099707 700__ $$0(orcid)0000-0002-7297-6104$$aSantabárbara, J.$$uUniversidad de Zaragoza
000099707 7102_ $$14009$$2730$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicología Básica
000099707 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000099707 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000099707 773__ $$g18, 4 (2021), 1370 [12 pp]$$pInt. j. environ. res. public health$$tInternational journal of environmental research and public health$$x1661-7827
000099707 8564_ $$s551508$$uhttps://zaguan.unizar.es/record/99707/files/texto_completo.pdf$$yVersión publicada
000099707 8564_ $$s2624644$$uhttps://zaguan.unizar.es/record/99707/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000099707 909CO $$ooai:zaguan.unizar.es:99707$$particulos$$pdriver
000099707 951__ $$a2023-05-18-14:57:38
000099707 980__ $$aARTICLE