doi:10.3390/ijerph18041370engVaquero-Puyuelo, D.De-La-Cámara, C.Olaya, B.Gracia-García, P.Lobo, A.López-Antón, R.Santabárbara, J.Anhedonia as a potential risk factor of alzheimer’s disease in a community-dwelling elderly sample: Results from the zarademp projectART-2021-123206(1) Introduction: Dementia is a major public health problem, and Alzheimer’s disease (AD) is the most frequent subtype. Clarifying the potential risk factors is necessary in order to improve dementia-prevention strategies and quality of life. Here, our purpose was to investigate the role of the absence of hedonic tone; anhedonia, understood as the reduction on previous enjoyable daily activities, which occasionally is underdetected and underdiagnosed; and the risk of developing AD in a cognitively unimpaired and non-depressed population sample. (2) Method: We used data from the Zaragoza Dementia and Depression (ZARADEMP) project, a longitudinal epidemiological study on dementia and depression. After excluding subjects with dementia, a sample of 2830 dwellers aged =65 years was followed for 4.5 years. The geriatric mental state examination was used to identify cases of anhedonia. AD was diagnosed by a panel of research psychiatrists according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria. A multivariate survival analysis and Cox proportional hazards regression model were performed, and the analysis was controlled by an analysis for the presence of clinically significant depression. (3) Results: We found a significant association between anhedonia cases and AD risk in the univariate analysis (hazard ratio (HR): 2.37; 95% CI: 1.04–5.40). This association persisted more strongly in the fully adjusted model. (4) Conclusions: Identifying cognitively intact individuals with anhedonia is a priority to implement preventive strategies that could delay the progression of cognitive and functional impairment in subjects at risk of AD.2021http://zaguan.unizar.es/record/9970710.3390/ijerph18041370http://zaguan.unizar.es/record/99707oai:zaguan.unizar.es:99707info:eu-repo/grantAgreement/ES/DGA/B15-17Rinfo:eu-repo/grantAgreement/ES/DGA-FEDER/PI16-00896info:eu-repo/grantAgreement/ES/DGA-FEDER/Una manera de hacer Europainfo:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/PI-19-01874info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321Einfo:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103International journal of environmental research and public health 18, 4 (2021), 1370 [12 pp]byhttp://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccess