99707 20230519145501.0 doi 10.3390/ijerph18041370 sideral 123206 ART-2021-123206 eng Vaquero-Puyuelo, D. Anhedonia as a potential risk factor of alzheimer’s disease in a community-dwelling elderly sample: Results from the zarademp project 2021 Access copy available to the general public Unrestricted (1) Introduction: Dementia is a major public health problem, and Alzheimer’s disease (AD) is the most frequent subtype. Clarifying the potential risk factors is necessary in order to improve dementia-prevention strategies and quality of life. Here, our purpose was to investigate the role of the absence of hedonic tone; anhedonia, understood as the reduction on previous enjoyable daily activities, which occasionally is underdetected and underdiagnosed; and the risk of developing AD in a cognitively unimpaired and non-depressed population sample. (2) Method: We used data from the Zaragoza Dementia and Depression (ZARADEMP) project, a longitudinal epidemiological study on dementia and depression. After excluding subjects with dementia, a sample of 2830 dwellers aged =65 years was followed for 4.5 years. The geriatric mental state examination was used to identify cases of anhedonia. AD was diagnosed by a panel of research psychiatrists according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria. A multivariate survival analysis and Cox proportional hazards regression model were performed, and the analysis was controlled by an analysis for the presence of clinically significant depression. (3) Results: We found a significant association between anhedonia cases and AD risk in the univariate analysis (hazard ratio (HR): 2.37; 95% CI: 1.04–5.40). This association persisted more strongly in the fully adjusted model. (4) Conclusions: Identifying cognitively intact individuals with anhedonia is a priority to implement preventive strategies that could delay the progression of cognitive and functional impairment in subjects at risk of AD. info:eu-repo/grantAgreement/ES/DGA/B15-17R info:eu-repo/grantAgreement/ES/DGA-FEDER/PI16-00896 info:eu-repo/grantAgreement/ES/DGA-FEDER/Una manera de hacer Europa info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/PI-19-01874 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/12-02254 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/16-00896 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562 info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.614 2021 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 45 / 183 = 0.246 2021 Q1 T1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 71 / 210 = 0.338 2021 Q2 T2 ENVIRONMENTAL SCIENCES 100 / 279 = 0.358 2021 Q2 T2 0.814 2021 Pollution 2021 Q1 Health, Toxicology and Mutagenesis 2021 Q1 4.5 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion De-La-Cámara, C. Universidad de Zaragoza (orcid)0000-0003-2284-7862 Olaya, B. Gracia-García, P. Universidad de Zaragoza (orcid)0000-0001-9822-6312 Lobo, A. Universidad de Zaragoza (orcid)0000-0002-9098-655X López-Antón, R. Universidad de Zaragoza (orcid)0000-0002-3360-7015 Santabárbara, J. Universidad de Zaragoza (orcid)0000-0002-7297-6104 4009 730 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicología Básica 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 18, 4 (2021), 1370 [12 pp] Int. j. environ. res. public health International journal of environmental research and public health 1661-7827 551508 http://zaguan.unizar.es/record/99707/files/texto_completo.pdf Versión publicada 2624644 http://zaguan.unizar.es/record/99707/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:99707 articulos driver 2023-05-18-14:57:38 ARTICLE