99724 20260113221444.0 doi 10.3390/ani11020381 sideral 123223 ART-2021-123223 eng De las Heras, M. Universidad de Zaragoza (orcid)0000-0003-3792-287X Neoplasia-associated wasting diseases with economic relevance in the sheep industry 2021 Access copy available to the general public Unrestricted We review three neoplastic wasting diseases affecting sheep generally recorded under common production cycles and with epidemiological and economic relevance in sheep-rearing countries: small intestinal adenocarcinoma (SIA), ovine pulmonary adenocarcinoma (OPA) and enzootic nasal adenocarcinoma (ENA). SIA is prevalent in Australia and New Zealand but present elsewhere in the world. This neoplasia is a tubular or signet-ring adenocarcinoma mainly located in the middle or distal term of the small intestine. Predisposing factors and aetiology are not known, but genetic factors or environmental carcinogens may be involved. OPA is a contagious lung cancer caused by jaagsiekte sheep retrovirus (JSRV) and has been reported in most sheep-rearing countries, resulting in significant economic losses. The disease is clinically characterized by a chronic respiratory process as a consequence of the development of lung adenocarcinoma. Diagnosis is based on the detection of JSRV in the tumour lesion by immunohistochemistry and PCR. In vivo diagnosis may be difficult, mainly in preclinical cases. ENA is a neoplasia of glands of the nasal mucosa and is associated with enzootic nasal tumour virus 1 (ENTV-1), which is similar to JSRV. ENA enzootically occurs in many countries of the world with the exception of Australia and New Zealand. The pathology associated with this neoplasia corresponds with a space occupying lesion histologically characterized as a low-grade adenocarcinoma. The combination of PCR and immunohistochemistry for diagnosis is advised. info:eu-repo/grantAgreement/ES/DGA/A15-17R info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 3.231 2021 VETERINARY SCIENCES 16 / 145 = 0.11 2021 Q1 T1 AGRICULTURE, DAIRY & ANIMAL SCIENCE 13 / 62 = 0.21 2021 Q1 T1 0.61 2021 Veterinary (miscellaneous) 2021 Q1 Animal Science and Zoology 2021 Q1 2.7 2021 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Borobia, M. Universidad de Zaragoza (orcid)0000-0002-0680-9957 Ortín, A. Universidad de Zaragoza (orcid)0000-0002-0313-5926 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 11, 2 (2021), 381 [18 pp] Animals (Basel) Animals 2076-2615 1020254 http://zaguan.unizar.es/record/99724/files/texto_completo.pdf Versión publicada 2583303 http://zaguan.unizar.es/record/99724/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:99724 articulos driver 2026-01-13-22:10:36 ARTICLE