000099726 001__ 99726
000099726 005__ 20230519145504.0
000099726 0247_ $$2doi$$a10.3390/pharmaceutics13020217
000099726 0248_ $$2sideral$$a123225
000099726 037__ $$aART-2021-123225
000099726 041__ $$aeng
000099726 100__ $$aRodrigo, M.J.
000099726 245__ $$aMonitoring new long-lasting intravitreal formulation for glaucoma with vitreous images using optical coherence tomography
000099726 260__ $$c2021
000099726 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099726 5203_ $$aIntravitreal injection is the gold standard therapeutic option for posterior segment patholo-gies, and long-lasting release is necessary to avoid reinjections. There is no effective intravitreal treatment for glaucoma or other optic neuropathies in daily practice, nor is there a non-invasive method to monitor drug levels in the vitreous. Here we show that a glaucoma treatment combining a hypotensive and neuroprotective intravitreal formulation (IF) of brimonidine–Laponite (BRI/LAP) can be monitored non-invasively using vitreoretinal interface imaging captured with optical coherence tomography (OCT) over 24 weeks of follow-up. Qualitative and quantitative characterisation was achieved by analysing the changes in vitreous (VIT) signal intensity, expressed as a ratio of retinal pigment epithelium (RPE) intensity. Vitreous hyperreflective aggregates mixed in the vitreous and tended to settle on the retinal surface. Relative intensity and aggregate size progressively decreased over 24 weeks in treated rat eyes as the BRI/LAP IF degraded. VIT/RPE relative intensity and total aggregate area correlated with brimonidine levels measured in the eye. The OCT-derived VIT/RPE relative intensity may be a useful and objective marker for non-invasive monitoring of BRI/LAP IF.
000099726 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/M17-00213$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01946$$9info:eu-repo/grantAgreement/ES/MINECO-AEI-FEDER/MAT2017-83858-C2-2
000099726 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000099726 590__ $$a6.525$$b2021
000099726 592__ $$a0.922$$b2021
000099726 594__ $$a6.0$$b2021
000099726 591__ $$aPHARMACOLOGY & PHARMACY$$b39 / 279 = 0.14$$c2021$$dQ1$$eT1
000099726 593__ $$aPharmaceutical Science$$c2021$$dQ1
000099726 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000099726 700__ $$0(orcid)0000-0003-0669-777X$$aPérez Del Palomar, A.$$uUniversidad de Zaragoza
000099726 700__ $$0(orcid)0000-0001-7248-4399$$aMontolío, A.$$uUniversidad de Zaragoza
000099726 700__ $$0(orcid)0000-0001-6072-1545$$aMendez-Martinez, S.$$uUniversidad de Zaragoza
000099726 700__ $$aSubias, M.
000099726 700__ $$0(orcid)0000-0002-7914-4685$$aCardiel, M.J.$$uUniversidad de Zaragoza
000099726 700__ $$aMartinez-Rincon, T.
000099726 700__ $$0(orcid)0000-0002-2967-6747$$aCegoñino, J.$$uUniversidad de Zaragoza
000099726 700__ $$0(orcid)0000-0002-0136-5138$$aFraile, J.M.
000099726 700__ $$0(orcid)0000-0002-4921-4734$$aVispe, E.
000099726 700__ $$0(orcid)0000-0003-1570-4257$$aMayoral, J.A.$$uUniversidad de Zaragoza
000099726 700__ $$0(orcid)0000-0002-1402-3129$$aPolo, V.$$uUniversidad de Zaragoza
000099726 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E.$$uUniversidad de Zaragoza
000099726 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000099726 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000099726 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000099726 7102_ $$11013$$2020$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Anatomía Patológica
000099726 773__ $$g13, 2 (2021), 217 [16 pp]$$pPharmaceutics$$tPharmaceutics$$x1999-4923
000099726 8564_ $$s898427$$uhttps://zaguan.unizar.es/record/99726/files/texto_completo.pdf$$yVersión publicada
000099726 8564_ $$s2706904$$uhttps://zaguan.unizar.es/record/99726/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000099726 909CO $$ooai:zaguan.unizar.es:99726$$particulos$$pdriver
000099726 951__ $$a2023-05-18-15:03:33
000099726 980__ $$aARTICLE