000099727 001__ 99727
000099727 005__ 20230519145504.0
000099727 0247_ $$2doi$$a10.3390/biom11020204
000099727 0248_ $$2sideral$$a123226
000099727 037__ $$aART-2021-123226
000099727 041__ $$aeng
000099727 100__ $$aGuijarro, I.M.
000099727 245__ $$aNeuroimmune response mediated by cytokines in natural scrapie after chronic dexamethasone treatment
000099727 260__ $$c2021
000099727 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099727 5203_ $$aThe actual role of prion protein-induced glial activation and subsequent cytokine secretion during prion diseases is still incompletely understood. The overall aim of this study is to assess the effect of an anti-inflammatory treatment with dexamethasone on different cytokines released by neuroglial cells that are potentially related to neuroinflammation in natural scrapie. This study emphasizes the complex interactions existent among several pleiotropic neuromodulator peptides and provides a global approach to clarify neuroinflammatory processes in prion diseases. Addition-ally, an impairment of communication between microglial and astroglial populations mediated by cytokines, mainly IL-1, is suggested. The main novelty of this study is that it is the first one assessing in situ neuroinflammatory activity in relation to chronic anti-inflammatory therapy, gaining relevance because it is based on a natural model. The cytokine profile data would suggest the activation of some neurotoxicity-associated route. Consequently, targeting such a pathway might be a new approach to modify the damaging effects of neuroinflammation.
000099727 536__ $$9info:eu-repo/grantAgreement/EUR/INTERREG-POCTEFA/EFA-148-16 REDPRION$$9info:eu-repo/grantAgreement/ES/MEC/FPU15-03524
000099727 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000099727 590__ $$a6.064$$b2021
000099727 592__ $$a1.019$$b2021
000099727 594__ $$a5.7$$b2021
000099727 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b75 / 297 = 0.253$$c2021$$dQ2$$eT1
000099727 593__ $$aMolecular Biology$$c2021$$dQ2
000099727 593__ $$aBiochemistry$$c2021$$dQ2
000099727 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000099727 700__ $$0(orcid)0000-0002-1756-5492$$aGarcés, M.$$uUniversidad de Zaragoza
000099727 700__ $$aAndrés-Benito, P.
000099727 700__ $$0(orcid)0000-0002-1590-3347$$aMarín, B.$$uUniversidad de Zaragoza
000099727 700__ $$0(orcid)0000-0001-9075-2764$$aOtero, A.$$uUniversidad de Zaragoza
000099727 700__ $$0(orcid)0000-0002-7037-6316$$aBarrio, T.
000099727 700__ $$aCarmona, M.
000099727 700__ $$aFerrer, I.
000099727 700__ $$0(orcid)0000-0002-7173-7216$$aBadiola, J.J.$$uUniversidad de Zaragoza
000099727 700__ $$0(orcid)0000-0002-2787-9671$$aMonzón, M.$$uUniversidad de Zaragoza
000099727 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000099727 7102_ $$11003$$2443$$aUniversidad de Zaragoza$$bDpto. Anatom.Histolog.Humanas$$cArea Histología
000099727 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000099727 773__ $$g11, 2 (2021), 204 [18 pp]$$tBiomolecules$$x2218-273X
000099727 8564_ $$s1104732$$uhttps://zaguan.unizar.es/record/99727/files/texto_completo.pdf$$yVersión publicada
000099727 8564_ $$s2747666$$uhttps://zaguan.unizar.es/record/99727/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000099727 909CO $$ooai:zaguan.unizar.es:99727$$particulos$$pdriver
000099727 951__ $$a2023-05-18-15:03:38
000099727 980__ $$aARTICLE