99727 20230519145504.0 doi 10.3390/biom11020204 sideral 123226 ART-2021-123226 eng Guijarro, I.M. Neuroimmune response mediated by cytokines in natural scrapie after chronic dexamethasone treatment 2021 Access copy available to the general public Unrestricted The actual role of prion protein-induced glial activation and subsequent cytokine secretion during prion diseases is still incompletely understood. The overall aim of this study is to assess the effect of an anti-inflammatory treatment with dexamethasone on different cytokines released by neuroglial cells that are potentially related to neuroinflammation in natural scrapie. This study emphasizes the complex interactions existent among several pleiotropic neuromodulator peptides and provides a global approach to clarify neuroinflammatory processes in prion diseases. Addition-ally, an impairment of communication between microglial and astroglial populations mediated by cytokines, mainly IL-1, is suggested. The main novelty of this study is that it is the first one assessing in situ neuroinflammatory activity in relation to chronic anti-inflammatory therapy, gaining relevance because it is based on a natural model. The cytokine profile data would suggest the activation of some neurotoxicity-associated route. Consequently, targeting such a pathway might be a new approach to modify the damaging effects of neuroinflammation. info:eu-repo/grantAgreement/EUR/INTERREG-POCTEFA/EFA-148-16 REDPRION info:eu-repo/grantAgreement/ES/MEC/FPU15-03524 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.064 2021 BIOCHEMISTRY & MOLECULAR BIOLOGY 75 / 297 = 0.253 2021 Q2 T1 1.019 2021 Molecular Biology 2021 Q2 Biochemistry 2021 Q2 5.7 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Garcés, M. Universidad de Zaragoza (orcid)0000-0002-1756-5492 Andrés-Benito, P. Marín, B. Universidad de Zaragoza (orcid)0000-0002-1590-3347 Otero, A. Universidad de Zaragoza (orcid)0000-0001-9075-2764 Barrio, T. (orcid)0000-0002-7037-6316 Carmona, M. Ferrer, I. Badiola, J.J. Universidad de Zaragoza (orcid)0000-0002-7173-7216 Monzón, M. Universidad de Zaragoza (orcid)0000-0002-2787-9671 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 11, 2 (2021), 204 [18 pp] Biomolecules 2218-273X 1104732 http://zaguan.unizar.es/record/99727/files/texto_completo.pdf Versión publicada 2747666 http://zaguan.unizar.es/record/99727/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:99727 articulos driver 2023-05-18-15:03:38 ARTICLE