000099729 001__ 99729 000099729 005__ 20230519145504.0 000099729 0247_ $$2doi$$a10.3390/antiox10020243 000099729 0248_ $$2sideral$$a123228 000099729 037__ $$aART-2021-123228 000099729 041__ $$aeng 000099729 100__ $$aQuero, J. 000099729 245__ $$aGrape stem extracts with potential anticancer and antioxidant properties 000099729 260__ $$c2021 000099729 5060_ $$aAccess copy available to the general public$$fUnrestricted 000099729 5203_ $$aThe application of plant extracts for therapeutic purposes has been used in traditional medicine because plants contain bioactive compounds with beneficial properties for health. Currently, the use of these compounds that are rich in polyphenols for the treatment and prevention of diseases such as cancer, diabetes, and cardiovascular diseases, many of them related to oxidative stress, is gaining certain relevance. Polyphenols have been shown to have antimutagenic, antioxidant, and anti-inflammatory properties. Therefore, the objective of the present work was to study the potential effect of grape stem extracts (GSE), rich in phenolic compounds, in the treatment of cancer, as well as their role in the prevention of this disease associated with its antioxidant power. For that purpose, three cancer lines (Caco-2, MCF-7, and MDA-MB-231) were used, and the results showed that grape stem extracts were capable of showing an antiproliferative effect in these cells through apoptosis cell death associated with a modification of the mitochondrial potential and reactive oxygen species (ROS) levels. Additionally, grape stem extracts showed an antioxidant effect on differentiated intestinal cells that could protect the intestine from diseases related to oxidative stress. Therefore, grape extracts contain bioactive principles with important biological properties and could be used as bio-functional food ingredients to prevent diseases or even to improve certain aspects of human health. 000099729 536__ $$9info:eu-repo/grantAgreement/ES/CIBERObn/CB06-03-1012$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B16-17R$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Otra manera de hacer Europa$$9info:eu-repo/grantAgreement/EUR/INTERREG-POCTEFA/EFA 220-11-ELENA$$9info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R$$9info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/Redvalue-SOE1-PI-E0123 000099729 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000099729 590__ $$a7.675$$b2021 000099729 592__ $$a1.008$$b2021 000099729 594__ $$a6.5$$b2021 000099729 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b50 / 297 = 0.168$$c2021$$dQ1$$eT1 000099729 593__ $$aBiochemistry$$c2021$$dQ1 000099729 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b12 / 144 = 0.083$$c2021$$dQ1$$eT1 000099729 593__ $$aPhysiology$$c2021$$dQ1 000099729 591__ $$aCHEMISTRY, MEDICINAL$$b4 / 63 = 0.063$$c2021$$dQ1$$eT1 000099729 593__ $$aMolecular Biology$$c2021$$dQ1 000099729 593__ $$aClinical Biochemistry$$c2021$$dQ1 000099729 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000099729 700__ $$aJiménez-Moreno, N. 000099729 700__ $$aEsparza, I. 000099729 700__ $$0(orcid)0000-0002-8251-8457$$aOsada, J.$$uUniversidad de Zaragoza 000099729 700__ $$0(orcid)0000-0003-2457-3674$$aCerrada, E.$$uUniversidad de Zaragoza 000099729 700__ $$aAncín-Azpilicueta, C. 000099729 700__ $$0(orcid)0000-0002-3595-7668$$aRodríguez-Yoldi, M.J.$$uUniversidad de Zaragoza 000099729 7102_ $$12010$$2760$$aUniversidad de Zaragoza$$bDpto. Química Inorgánica$$cÁrea Química Inorgánica 000099729 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología 000099729 7102_ $$11002$$2060$$aUniversidad de Zaragoza$$bDpto. Bioq.Biolog.Mol. Celular$$cÁrea Bioquímica y Biolog.Mole. 000099729 773__ $$g10, 2 (2021), 243 [17 pp]$$pAntioxidants$$tAntioxidants$$x2076-3921 000099729 8564_ $$s660833$$uhttps://zaguan.unizar.es/record/99729/files/texto_completo.pdf$$yVersión publicada 000099729 8564_ $$s2645450$$uhttps://zaguan.unizar.es/record/99729/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000099729 909CO $$ooai:zaguan.unizar.es:99729$$particulos$$pdriver 000099729 951__ $$a2023-05-18-15:04:06 000099729 980__ $$aARTICLE