99729 20230519145504.0 doi 10.3390/antiox10020243 sideral 123228 ART-2021-123228 eng Quero, J. Grape stem extracts with potential anticancer and antioxidant properties 2021 Access copy available to the general public Unrestricted The application of plant extracts for therapeutic purposes has been used in traditional medicine because plants contain bioactive compounds with beneficial properties for health. Currently, the use of these compounds that are rich in polyphenols for the treatment and prevention of diseases such as cancer, diabetes, and cardiovascular diseases, many of them related to oxidative stress, is gaining certain relevance. Polyphenols have been shown to have antimutagenic, antioxidant, and anti-inflammatory properties. Therefore, the objective of the present work was to study the potential effect of grape stem extracts (GSE), rich in phenolic compounds, in the treatment of cancer, as well as their role in the prevention of this disease associated with its antioxidant power. For that purpose, three cancer lines (Caco-2, MCF-7, and MDA-MB-231) were used, and the results showed that grape stem extracts were capable of showing an antiproliferative effect in these cells through apoptosis cell death associated with a modification of the mitochondrial potential and reactive oxygen species (ROS) levels. Additionally, grape stem extracts showed an antioxidant effect on differentiated intestinal cells that could protect the intestine from diseases related to oxidative stress. Therefore, grape extracts contain bioactive principles with important biological properties and could be used as bio-functional food ingredients to prevent diseases or even to improve certain aspects of human health. info:eu-repo/grantAgreement/ES/CIBERObn/CB06-03-1012 info:eu-repo/grantAgreement/ES/DGA-FEDER/B16-17R info:eu-repo/grantAgreement/ES/DGA-FEDER/Otra manera de hacer Europa info:eu-repo/grantAgreement/EUR/INTERREG-POCTEFA/EFA 220-11-ELENA info:eu-repo/grantAgreement/ES/MINECO/SAF2016-75441-R info:eu-repo/grantAgreement/EUR/SUDOE/INTERREG/Redvalue-SOE1-PI-E0123 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 7.675 2021 BIOCHEMISTRY & MOLECULAR BIOLOGY 50 / 297 = 0.168 2021 Q1 T1 FOOD SCIENCE & TECHNOLOGY 12 / 144 = 0.083 2021 Q1 T1 CHEMISTRY, MEDICINAL 4 / 63 = 0.063 2021 Q1 T1 1.008 2021 Biochemistry 2021 Q1 Physiology 2021 Q1 Molecular Biology 2021 Q1 Clinical Biochemistry 2021 Q1 6.5 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Jiménez-Moreno, N. Esparza, I. Osada, J. Universidad de Zaragoza (orcid)0000-0002-8251-8457 Cerrada, E. Universidad de Zaragoza (orcid)0000-0003-2457-3674 Ancín-Azpilicueta, C. Rodríguez-Yoldi, M.J. Universidad de Zaragoza (orcid)0000-0002-3595-7668 2010 760 Universidad de Zaragoza Dpto. Química Inorgánica Área Química Inorgánica 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 10, 2 (2021), 243 [17 pp] Antioxidants Antioxidants 2076-3921 660833 http://zaguan.unizar.es/record/99729/files/texto_completo.pdf Versión publicada 2645450 http://zaguan.unizar.es/record/99729/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:99729 articulos driver 2023-05-18-15:04:06 ARTICLE