000099754 001__ 99754
000099754 005__ 20230519145400.0
000099754 0247_ $$2doi$$a10.3390/v13010093
000099754 0248_ $$2sideral$$a123274
000099754 037__ $$aART-2021-123274
000099754 041__ $$aeng
000099754 100__ $$aCañada, J.E.
000099754 245__ $$aIdentification of a New HIV-1 BC Intersubtype Circulating Recombinant Form (CRF108_BC) in Spain
000099754 260__ $$c2021
000099754 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099754 5203_ $$aThe extraordinary genetic variability of human immunodeficiency virus type 1 (HIV-1) group M has led to the identification of 10 subtypes, 102 circulating recombinant forms (CRFs) and numerous unique recombinant forms. Among CRFs, 11 derived from subtypes B and C have been identified in China, Brazil, and Italy. Here we identify a new HIV-1 CRF_BC in Northern Spain. Originally, a phylogenetic cluster of 15 viruses of subtype C in protease-reverse transcriptase was identified in an HIV-1 molecular surveillance study in Spain, most of them from individuals from the Basque Country and heterosexually transmitted. Analyses of near full-length genome sequences from six viruses from three cities revealed that they were BC recombinant with coincident mosaic structures different from known CRFs. This allowed the definition of a new HIV-1 CRF designated CRF108_BC, whose genome is predominantly of subtype C, with four short subtype B fragments. Phylogenetic analyses with database sequences supported a Brazilian ancestry of the parental subtype C strain. Coalescent Bayesian analyses estimated the most recent common ancestor of CRF108_BC in the city of Vitoria, Basque Country, around 2000. CRF108_BC is the first CRF_BC identified in Spain and the second in Europe, after CRF60_BC, both phylogenetically related to Brazilian subtype C strains.
000099754 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-AESI/PI16CIII-00033$$9info:eu-repo/grantAgreement/ES/ISCIII-AESI/PI19CIII-00042$$9info:eu-repo/grantAgreement/ES/ISCIII-RIS-FEDER/RD16ISCIII-0002-0004
000099754 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000099754 590__ $$a5.818$$b2021
000099754 592__ $$a1.463$$b2021
000099754 594__ $$a6.6$$b2021
000099754 591__ $$aVIROLOGY$$b14 / 37 = 0.378$$c2021$$dQ2$$eT2
000099754 593__ $$aVirology$$c2021$$dQ1
000099754 593__ $$aInfectious Diseases$$c2021$$dQ1
000099754 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000099754 700__ $$aDelgado, E.
000099754 700__ $$aGil, H.
000099754 700__ $$aSánchez, M.
000099754 700__ $$aBenito, S.
000099754 700__ $$aGarcía-Bodas, E.
000099754 700__ $$aGómez-González, C.
000099754 700__ $$aCanut-Blasco, A.
000099754 700__ $$aPortu-Zapirain, J.
000099754 700__ $$aSáez de Adana, E.
000099754 700__ $$aDe la Peña, M.
000099754 700__ $$aIbarra, S.
000099754 700__ $$aCilla, G.
000099754 700__ $$aIribarren, J.A.
000099754 700__ $$aMartínez-Sapiña, A.
000099754 700__ $$aThomson, M.M.
000099754 773__ $$g13, 1 (2021), 93 [13 pp]$$pVIRUSES-BASEL$$tVIRUSES-BASEL$$x1999-4915
000099754 8564_ $$s863301$$uhttps://zaguan.unizar.es/record/99754/files/texto_completo.pdf$$yVersión publicada
000099754 8564_ $$s2713703$$uhttps://zaguan.unizar.es/record/99754/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000099754 909CO $$ooai:zaguan.unizar.es:99754$$particulos$$pdriver
000099754 951__ $$a2023-05-18-13:37:06
000099754 980__ $$aARTICLE