99777 20230519145513.0 doi 10.3390/toxins13020085 sideral 123256 ART-2021-123256 eng Esteban, P. In Vitro and In Vivo Antibacterial Activity of Gliotoxin Alone and in Combination with Antibiotics against Staphylococcus aureus 2021 Access copy available to the general public Unrestricted Multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus (MRSA) is one of the major causes of hospital-acquired and community infections and pose a challenge to the human health care system. Therefore, it is important to find new drugs that show activity against these bacteria, both in monotherapy and in combination with other antimicrobial drugs. Gliotoxin (GT) is a mycotoxin produced by Aspergillus fumigatus and other fungi of the Aspergillus genus. Some evidence suggests that GT shows antimicrobial activity against S. aureus in vitro, albeit its efficacy against multidrug-resistant strains such asMRSA or vancomycin-intermediate S. aureus (VISA) strainsis not known. This work aimedto evaluate the antibiotic efficacy of GT as monotherapy or in combination with other therapeutics against MRSA in vitro and in vivo using a Caenorhabditis elegans infection model. info:eu-repo/grantAgreement/ES/DGA-FEDER/B29-17R info:eu-repo/grantAgreement/ES/MCIU-AEI/SAF2017-83120-C2-1-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.075 2021 TOXICOLOGY 20 / 94 = 0.213 2021 Q1 T1 FOOD SCIENCE & TECHNOLOGY 40 / 144 = 0.278 2021 Q2 T1 0.884 2021 Toxicology 2021 Q1 Health, Toxicology and Mutagenesis 2021 Q1 6.6 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Redrado, S. Comas, L. Domingo, M.P. Millán-Lou, M.I. Seral, C. Universidad de Zaragoza (orcid)0000-0002-9742-1463 Algarate, S. Universidad de Zaragoza (orcid)0000-0002-0036-6630 Lopez, C. Universidad de Zaragoza Rezusta, A. Universidad de Zaragoza (orcid)0000-0001-7294-245X Pardo, J. Universidad de Zaragoza (orcid)0000-0003-0154-0730 Arias, M. Galvez, E.M. 1006 255 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Enfermería 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 1011 566 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Inmunología 13, 2 (2021), 85 [16 pp] Toxins Toxins 2072-6651 645822 http://zaguan.unizar.es/record/99777/files/texto_completo.pdf Versión publicada 2578058 http://zaguan.unizar.es/record/99777/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:99777 articulos driver 2023-05-18-15:13:08 ARTICLE