000099788 001__ 99788
000099788 005__ 20230519145409.0
000099788 0247_ $$2doi$$a10.37201/req/085.2020
000099788 0248_ $$2sideral$$a123345
000099788 037__ $$aART-2021-123345
000099788 041__ $$aeng
000099788 100__ $$aEsteban-Rihuete, M.
000099788 245__ $$aClostridioides difficile infection in a long-term convalescence hospital: A real tale of pitfalls and outdated therapy
000099788 260__ $$c2021
000099788 5060_ $$aAccess copy available to the general public$$fUnrestricted
000099788 5203_ $$aObjective. The aim of the study was to know the char-acteristics and risk factors of Clostridioides difficile infection (CDI) in a long-term hospital is key to improve its manage-ment.
Material and methods. Retrospective study with 37 pa-tients, along 43 months. We describe demographic variables, clinical data, time to diagnosis, treatment, and evolution.
Results. Analysis of 46 episodes (37 patients, mean age=82.2 years). 77.8% were absolutely dependent, 41.7% had chronic kidney disease, 64.9% had received antibiotics in the previous three months, 40.5% received antibiotics at diagnosis. It was the first episode in 78.4%, and first recurrence in 21.6%. Therapy was started in the first 24 hours after diagnosis in 89.2%, mostly metronidazole. 83.3% recovered, 3 patients died from CDI, diagnosis was registered in the discharge report in 91.1%.
Conclusions. Previous antibiotic therapy, high grade of dependency and renal failure were the main risk factors. There is room for improvement in CDI management at our hospital.
Objective. The aim of the study was to know the characteristics and risk factors of Clostridioides difficile infection (CDI) in a long-term hospital is key to improve its management.
Material and methods. Retrospective study with 37 patients, along 43 months. We describe demographic variables, clinical data, time to diagnosis, treatment, and evolution.
Results. Analysis of 46 episodes (37 patients, mean age=82.2 years). 77.8% were absolutely dependent, 41.7% had chronic kidney disease, 64.9% had received antibiotics in the previous three months, 40.5% received antibiotics at diagnosis. It was the first episode in 78.4%, and first recurrence in 21.6%. Therapy was started in the first 24 hours after diagnosis in 89.2%, mostly metronidazole. 83.3% recovered, 3 patients died from CDI, diagnosis was registered in the discharge report in 91.1%.
Conclusions. Previous antibiotic therapy, high grade of dependency and renal failure were the main risk factors. There is room for improvement in CDI management at our hospital.
000099788 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000099788 590__ $$a2.515$$b2021
000099788 592__ $$a0.44$$b2021
000099788 594__ $$a2.3$$b2021
000099788 591__ $$aPHARMACOLOGY & PHARMACY$$b206 / 279 = 0.738$$c2021$$dQ3$$eT3
000099788 593__ $$aMicrobiology (medical)$$c2021$$dQ3
000099788 591__ $$aMICROBIOLOGY$$b116 / 138 = 0.841$$c2021$$dQ4$$eT3
000099788 593__ $$aMedicine (miscellaneous)$$c2021$$dQ3
000099788 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000099788 700__ $$aMoreno-Borraz, L.
000099788 700__ $$aRodríguez-Gascón, D.
000099788 700__ $$aGarcía-Herrero, J.C.
000099788 700__ $$0(orcid)0000-0002-9582-5472$$aGarcía-Lechuz, J.M.
000099788 700__ $$aGarcía-Forcada, Á.
000099788 773__ $$g34, 1 (2021), 51-55$$pRev. esp. quimioter.$$tRevista española de quimioterapia$$x0214-3429
000099788 8564_ $$s95481$$uhttps://zaguan.unizar.es/record/99788/files/texto_completo.pdf$$yVersión publicada
000099788 8564_ $$s2420990$$uhttps://zaguan.unizar.es/record/99788/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000099788 909CO $$ooai:zaguan.unizar.es:99788$$particulos$$pdriver
000099788 951__ $$a2023-05-18-13:53:34
000099788 980__ $$aARTICLE