99816 20230519145418.0 doi 10.1007/s10096-020-04139-5 sideral 123386 ART-2021-123386 eng Fuentes, A. Antibody response in patients admitted to the hospital with suspected SARS-CoV-2 infection: results from a multicenter study across Spain 2021 Access copy available to the general public Unrestricted Aim: To evaluate the serological response against SARS-CoV-2 in a multicenter study representative of the Spanish COVID pandemic. Methods: IgG and IgM + IgA responses were measured on 1466 samples from 1236 Spanish COVID-19 patients admitted to the hospital, two commercial ELISA kits (Vircell SL, Spain) based on the detection of antibodies against the viral spike protein and nucleoprotein, were used. Results: Approximately half of the patients presented antibodies (56.8% were IgM + IgA positive and 43.0% were IgG positive) as soon as 2 days after the first positive PCR result. Serological test positivity increased with time from the PCR test, and 10 days after the first PCR result, 91.5% and 88.0% of the patients presented IgM + IgA and IgG antibodies, respectively. Conclusion: The high values of sensitivity attained in the present study from a relatively early period of time after hospitalization support the use of the evaluated serological assays as supplementary diagnostic tests for the clinical management of COVID-19. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.103 2021 MICROBIOLOGY 49 / 138 = 0.355 2021 Q2 T2 INFECTIOUS DISEASES 41 / 96 = 0.427 2021 Q2 T2 1.205 2021 Medicine (miscellaneous) 2021 Q1 Infectious Diseases 2021 Q1 6.7 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Serrano-Conde, E. Roldán, C. Benito-Ruesca, R. Universidad de Zaragoza (orcid)0000-0001-5134-1006 Mejías, G. Sampedro, A. March-Roselló, G. Fernández-Natal, I. Esperalba, J. Rodríguez, M.J. Martínez de Aguirre, P. Salas, C. Roc, M.L. Soria, L.M. Parra-Grande, M. Montero, M.D. Fernández-Roblas, R. Franco-Álvarez de Luna, F. Lozano, C. García, F. 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 40 (2021), 1343–1349 Eur. j. clin. microbiol. infect. dis. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 0934-9723 800549 http://zaguan.unizar.es/record/99816/files/texto_completo.pdf Versión publicada 1978892 http://zaguan.unizar.es/record/99816/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:99816 articulos driver 2023-05-18-14:03:17 ARTICLE