Devastadora complicación tras tratamiento con aflibercept

Echazarreta-Gallego, E. ; Elía-Guedea, M. (Universidad de Zaragoza) ; Córdoba-Díaz de Laspra, E.

Resumen: Background The use of a new chemotherapy as adjuvant treatment of colorectal cancer is not free of complications. Monoclonal antibodies are associated with bleeding and intestinal perforations. Objective To report the case of a patient who developed a serious complication after treatment with an antiangiogenic drug for colorectal neoplasm. Clinical case The case is presented of a 42-year-old male operated on due to subocclusive rectal cancer with metástasis at the time of diagnosis. Sixteen months after surgery during second-line adjuvant therapy, an intestinal perforation was observed with haemorrhage and intestinal leak to retroperitoneum and left lower extremity. Despite intensive medical and surgical treatment this complication had fatal consequences. Conclusions Future research should be directed at obtaining biomarkers for the specific use of antiangiogenic agents in order to decrease the rate of adverse factors.

Idioma: Español

DOI: 10.1016/j.circir.2016.03.011

Año: 2017

Publicado en: Cirugia y Cirujanos 85, 3 (2017), 260-263
ISSN: 0009-7411

Factor impacto JCR: 0.427 (2017)

Categ. JCR: SURGERY rank: 191 / 200 = 0.955 (2017) - Q4 - T3

Factor impacto SCIMAGO: 0.17 - Surgery (Q4)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Cirugía (Dpto. Cirugía,Ginecol.Obstetr.)