Hemoptysis as the first symptom in the diagnosis of metastatic choriocarcinoma in the third trimester of pregnancy: A case report

Álvarez-Sarrado, Leticia ; González-Ballano, Isabel (Universidad de Zaragoza) ; Herrero-Serrano, Rebeca ; Giménez-Molina, Claudia ; Rodríguez-Solanilla, Belén ; Campillos-Maza, José Manuel (Universidad de Zaragoza)

Resumen: Introduction: Choriocarcinoma is a rare neoplasm (1/40000 pregnancies). In the context of a viable pregnancy, the incidence is even lower (1/160000). Case report: A woman in her second pregnancy was admitted at 31 + 6 weeks of gestation with hemoptysis and abnormal vaginal bleeding. Numerous placental venous lakes, bilateral pulmonary nodules and a pleural effusion were found. Pleural fluid ß-HCG levels were elevated and a brain-chest-abdominal-pelvic CT scan led to the diagnosis of a high-risk gestational trophoblastic neoplasm. A caesarean section at 32 + 1 weeks of gestation was performed. Six cycles of an EMA-CO chemotherapy regime were administered. ß-HCG levels normalized after 3 cycles. Placental histopathology confirmed the presence of a gestational choriocarcinoma. Conclusion: Choriocarcinoma is a highly aggressive tumor. In high-risk tumors, combination chemotherapy is the first-line treatment, offering high remission rates. Treatment response is evaluated by monitoring blood ß-HCG levels, which should be long-term.

Idioma: Inglés

DOI: 10.1016/j.crwh.2020.e00211

Año: 2020

Publicado en: Case Reports in Women's Health 27 (2020), e00211 [4 pp.]
ISSN: 2214-9112

Factor impacto SCIMAGO: 0.259 - Obstetrics and Gynecology (Q3)

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Obstetricia y Ginecología (Dpto. Cirugía)