2026-04-22
08:39 |
Variant-dependent pharmacological rescue of phenylalanine hydroxylase supports a precision therapeutic strategy for phenylketonuria
Conde-Giménez, María ; Salillas, Sandra ; Galiana-Cameo, María ; Martínez-Oliván, Juan E. ; Mahía, Alejandro ; Ledesma, Manuel ; Galano-Frutos, Juan José ; Maity, Ritwik ; Velázquez-Campoy, Adrián ; Díaz-de-Villegas, María D. ; Hurtado-Guerrero, Ramón ; Sancho, Javier
- [BIOMEDICINE & PHARMACOTHERAPY 199 (2026), 119371 [15 pp.]- ISSN: 0753-3322]
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2026-04-18
10:52 |
Repurposing Drugs as Bacteroides fragilis BFT-3 Inhibitors in the Animal Infection Model Galleria mellonella
Jiménez-Alesanco, Ana ; Gómara-Lomero, Marta ; Jeblaoui, Hajar ; Vega, Sonia ; Velázquez-Campoy, Adrián ; Aínsa, José Antonio ; Abián, Olga
- [ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 1557, 1 (2026), 16- ISSN: 0077-8923]
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2026-04-18
10:52 |
Foldamers rescue synucleinopathy phenotypes in multiple in vitro and in vivo models
Dohoney, Ryan A. ; Palanikumar, L. ; Oldani, Emily ; Baysah, Charles Zuwu ; Joseph, Johnson A. ; Polanco, David ; Santos-Otte, Paula ; Stillman, Nicholas H. ; Corcoran, Peter ; Ball, Tyler D. ; Fitch, Tessa C. ; Ahmed, Jemil ; Ogbonna-Ukuku, Ifunayachi ; Reynolds Caicedo, Kevin M. ; Liu, Ying ; Leehey, Maureen A. ; Linseman, Daniel A. ; Paredes, Daniel A. ; Birol, Melissa ; Cremades, Nunilo ; Magzoub, Mazin ; Kumar, Sunil
- [SCIENCE TRANSLATIONAL MEDICINE 18, 843 (2026), [17 pp.]- ISSN: 1946-6234]
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2026-04-18
10:52 |
Calcium as a molecular switch that regulates Annexin A11 N- and C-terminal domains interaction and its role in ALS
Di Napoli, Giulia ; Alfurno, Lorenzo ; Fissore, Alex ; Raccuia, Eleonora ; Olivieri, Paolo ; Marengo, Mauro ; Oliaro-Bosso, Simonetta ; Piaz, Fabrizio Dal ; Catucci, Gianluca ; Gilardi, Gianfranco ; Velazquez-Campoy, Adrian ; Prischi, Filippo ; De Simone, Angela ; Spyrakis, Francesca ; Di Palma, Francesco ; Adinolfi, Salvatore
- [International journal of biological macromolecules 358, [9 pp.] (2026), 151719- ISSN: 0141-8130]
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2026-04-18
10:52 |
Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry
Rivero, Maribel ; Pacheco-Garcia, Juan Luis ; Vankova, Pavla ; Loginov, Dmitry ; Quereda-Moraleda, Isabel ; Martin-Garcia, Jose Manuel ; Man, Petr ; Pey, Angel Luis ; Medina, Milagros
- [FEBS Journal (2026), [27 pp.]- ISSN: 1742-464X]
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2026-03-26
14:45 |
Reversible phosphorylation influences energetic cellular metabolism by modulating mitochondrial gene expression
Mainé-Rodrigo, Aldara ; Vela-Sebastián, Ana ; Pacheu-Grau, David
- [TRENDS IN ENDOCRINOLOGY AND METABOLISM 37, 3 (2026), 186-189- ISSN: 1043-2760]
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2026-03-18
13:56 |
Minimized sample consumption for time-resolved serial crystallography applied to the redox cycle of human NQO1
Doppler, Diandra ; Grieco, Alice ; Koh, Domin ; Manna, Abhik ; Ansari, Adil ; Alvarez, Roberto ; Karpos, Konstantinos ; Le, Hung ; Sonker, Mukul ; Ketawala, Gihan K. ; Mahmud, Samira ; Quereda-Moraleda, Isabel ; Sen, Sayantee ; Pey, Angel L. ; Letrun, Romain ; Dörner, Katerina ; Koliyadu, Jayanath C. P. ; de Wijn, Raphael ; Bielecki, Johan ; Han, Huijong ; Kim, Chan ; Koua, Faisal H. M. ; Round, Adam ; Sarma, Abhisakh ; Sato, Tokushi ; Schmidt, Christina ; Vakili, Mohammad ; Zabelskii, Dmitrii ; Bean, Richard ; Mancuso, Adrian P. ; Schulz, Joachim ; Fromme, Raimund ; Medina, Milagros ; Grant, Thomas D. ; Fromme, Petra ; Kirian, Richard A. ; Botha, Sabine ; Manuel Martin-Garcia, Jose ; Ros, Alexandra
- [Communications Chemistry 9, 1 (2026), 14 pp.- ISSN: 2399-3669]
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2026-03-18
13:56 |
Multisite phosphorylation of the AML-linked C-terminal of nucleophosmin (NPM1) orchestrates protein stability, DNA binding and charge block-driven phase separation
Rivero-García, Pablo ; Giner-Arroyo, Rafael L ; Tamargo-Azpilicueta, Joaquín ; Telfer, Abbey ; Frezza , Elisa ; Velázquez-Campoy, Adrián ; Díaz-Moreno, Sofía ; De la Rosa, Miguel A. ; Díaz-Moreno, Irene
- [Nucleic Acids Research 54, 5 (2026), 17 pp.- ISSN: 0305-1048]
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2026-03-16
08:27 |
Unveiling nuclear localization signals in human arginine deiminase proteins
Neira, José L. ; Abian, Olga ; Velazquez-Campoy, Adrián ; Rizzuti, Bruno
- [Protein science 35, 4 (2026), [20 pp.]- ISSN: 0961-8368]
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2026-03-01
17:55 |
Effects of Tributyltin Chloride on Human Neuronal Differentiation and Mice Brain Development
López-Gallardo, Ester ; Meade, Patricia ; Jiménez-Salvador, Irene ; Hernández-Ainsa, Carmen ; Iglesias, Eldris ; Pesini, Alba ; Garrido-Pérez, Nuria ; Emperador, Sonia ; Pacheu-Grau, David ; Bayona-Bafaluy, Pilar ; Ruiz-Pesini, Eduardo
- [ENVIRONMENTAL TOXICOLOGY (2026), [16 pp.]- ISSN: 1520-4081]
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