Reversible phosphorylation influences energetic cellular metabolism by modulating mitochondrial gene expression

Mainé-Rodrigo, Aldara ; Vela-Sebastián, Ana (Universidad de Zaragoza) ; Pacheu-Grau, David (Universidad de Zaragoza)

Resumen: Mitochondria act as key metabolic regulators beyond ATP production, and the understanding of how cellular signaling modifies mitochondrial gene expression is currently being explored. Recent evidence links kinases such as mitogen-activated protein kinase-interacting kinases, hexokinase 1, and eukaryotic elongation factor 2 kinase to mitochondrial function, influencing metabolic adaptation, inflammation, and survival under nutrient stress, with implications for obesity and aging.

Idioma: Inglés

DOI: 10.1016/j.tem.2026.01.011

Año: 2026

Publicado en: TRENDS IN ENDOCRINOLOGY AND METABOLISM 37, 3 (2026), 186-189
ISSN: 1043-2760

Financiación: info:eu-repo/grantAgreement/ES/AEI/PID2023-147275NB-I00
Financiación: info:eu-repo/grantAgreement/ES/DGA/B33-23R
Financiación: info:eu-repo/grantAgreement/ES/MICINN/CNS2023-144637

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Bioquímica y Biolog.Mole. (Dpto. Bioq.Biolog.Mol. Celular)