Clinical and anatomopathological features of eosinophilic oesophagitis in children and adults

Agulló-García, A. ; Cubero, J.L. ; Lezaun, A. ; Boné, J. ; Guallar, I. ; Colás, C. (Universidad de Zaragoza)

Resumen: Introduction: Eosinophilic oesophagitis (EoE) is a chronic clinical-pathological disorder with an immunological basis characterised by symptoms of oesophageal dysfunction and, histologically, eosinophilic inflammation.
Objective: To evaluate the clinical characteristics and differences in children and adults diagnosed with EoE in a tertiary level hospital.
Method: Descriptive, retrospective and cross-sectional study. We randomly selected 40 children and 40 adults diagnosed with EoE between 2009 and 2016. The patient characteristics were analysed by means of epidemiological, clinical, diagnostic and therapeutic variables.
Results: The average age at diagnosis was 10 years (children) and 34 years (adults), with a higher frequency in males. The majority were sensitised to aeroallergens (77.5% children vs. 82.5% adults) and foods (75% children vs. 82.5% adults). Statistically significant differences were detected in sensitisation to fruits (p = 0.007) and grains (p < 0.001). Differences were observed in impaction (22.5% children vs. 82.5% adults), dysphagia (42.5% children vs. 77.5% adults) and abdominal pain (25% children vs. 7.5% adults). Endoscopy showed that children had a higher frequency of exudates (92.5%) and adults, trachealisation (50% vs. 5%) and stenosis (17.5% vs. 2.5%). Statistically significant differences were found in treatment with topical corticosteroids (30% children vs. 77.5% adults), with a variable positive response. 77.5% of the patients received elimination diets.
Conclusions: Statistically significant differences were observed between the paediatric and adult populations in the food sensitisation profiles, clinical manifestations, endoscopic findings and treatments received. This is a complex pathology that calls for a multidisciplinary team and would require new non-invasive techniques to facilitate its management.

Idioma: Inglés

DOI: 10.1016/j.aller.2020.03.009

Año: 2020

Publicado en: Allergologia et Immunopathologia 48, 6 (2020), 560-567
ISSN: 0301-0546

Factor impacto JCR: 1.667 (2020)

Categ. JCR: IMMUNOLOGY rank: 150 / 162 = 0.926 (2020) - Q4 - T3
Categ. JCR: ALLERGY rank: 24 / 28 = 0.857 (2020) - Q4 - T3

Factor impacto SCIMAGO: 0.482 - Immunology (Q3) - Pulmonary and Respiratory Medicine (Q3) - Medicine (miscellaneous) (Q3) - Immunology and Allergy (Q3)

Tipo y forma: Article (PostPrint)

Área (Departamento): Area Medicina (Dpto. Medicina, Psiqu. y Derm.)