Relationship between physical activity, oxidative stress, and total plasma antioxidant capacity in spanish children from the genobox study

Llorente-Cantarero, Francisco Jesús ; Aguilar-Gómez, Francisco Javier ; Leis, Rosaura ; Bueno, Gloria ; Rupérez, Azahara I. ; Anguita-Ruiz, Augusto ; Vázquez-Cobela, Rocío ; Mesa, María Dolores ; Moreno, Luis A. ; Gil, Ángel ; Aguilera, Concepción María ; Gil-Campos, Mercedes

Resumen: The World Health Organization has recommended performing at least 60 min a day of moderate-to-vigorous physical activity (MVPA) and reducing sedentarism in children and adolescents to offer significant health benefits and mitigate health risks. Physical fitness and sports practice seem to improve oxidative stress (OS) status during childhood. However, to our knowledge, there are no data regarding the influence of objectively-measured physical activity (PA) and sedentarism on OS status in children and adolescents. The present study aimed to evaluate the influence of moderate and vigorous PA and sedentarism on OS and plasma total antioxidant capacity (TAC) in a selected Spanish population of 216 children and adolescents from the GENOBOX study. PA (light, moderate, and vigorous) and sedentarism (i.e., sedentary time (ST)) were measured by accelerometry. A Physical Activity-Sedentarism Score (PASS) was developed integrating moderate and vigorous PA and ST levels. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and isoprostane F2a (F2-IsoPs), as markers of OS, were determined by ELISA; and TAC was estimated by colorimetry using an antioxidant kit. A higher PASS was associated with lower plasma TAC and urinary 8OHdG and F2-IsoPs, showing a better redox profile. Reduced OS markers (8-OHdG and F2-IsoPs) in children with higher PASS may diminish the need of maintaining high concentrations of antioxidants in plasma during rest to achieve redox homeostasis.

Idioma: Inglés

DOI: 10.3390/antiox10020320

Año: 2021

Publicado en: Antioxidants 10, 2 (2021), 320 [14 pp.]
ISSN: 2076-3921

Factor impacto JCR: 7.675 (2021)

Categ. JCR: BIOCHEMISTRY & MOLECULAR BIOLOGY rank: 50 / 297 = 0.168 (2021) - Q1 - T1
Categ. JCR: FOOD SCIENCE & TECHNOLOGY rank: 12 / 144 = 0.083 (2021) - Q1 - T1
Categ. JCR: CHEMISTRY, MEDICINAL rank: 4 / 63 = 0.063 (2021) - Q1 - T1

Factor impacto CITESCORE: 6.5 - Biochemistry, Genetics and Molecular Biology (Q2)

Factor impacto SCIMAGO: 1.008 - Biochemistry (Q1) - Physiology (Q1) - Molecular Biology (Q1) - Clinical Biochemistry (Q1)

Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-01425
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02042
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02059
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-00871
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01205
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-01301
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/i-PFIS-IFI17-00048
Financiación: info:eu-repo/grantAgreement/ES/MSCBS-ISCIII-FEDER/RETICS-RD12-0026-0015

Tipo y forma: Article (Published version)