Time-dependent in silico modelling of orthognathic surgery to support the design of biodegradable bone plates
Financiación H2020 / H2020 Funds
Resumen: Orthognathic surgery is performed to realign the jaws of a patient through several osteotomies. The state-of- the-art bone plates used to maintain the bone fragments in place are made of titanium. The presence of these non-degradable plates can have unwanted side effects on the long term (e.g. higher infection risk) if they are not removed. Using a biodegradable material such as magnesium may be a possible solution to this problem. However, biodegradation leads to a decrease of mechanical strength, therefore a time-dependent computational approach can help to evaluate the performance of such plates. In the present work, a computational framework has been developed to include biodegradation and bone healing algorithms in a finite element model. It includes bone plates and the mandible, which are submitted to masticatory loads during the early healing period (two months following the surgery). Two different bone plate designs with different stiffnesses have been tested. The stiff design exhibited good mechanical stability, with maximum Von Mises stress being less than 40% of the yield strength throughout the simulation. The flexible design shows high stresses when the bone healing has not started in the fracture gaps, indicating possible failure of the plate. However, this design leads to a higher bone healing quality after two months, as more cartilage is formed due to higher strains exerted in fracture gaps. We therefore conclude that in silico modelling can support tuning of the design parameters to ensure mechanical stability and while promoting bone healing.
Idioma: Inglés
DOI: 10.1016/j.jmbbm.2021.104641
Año: 2021
Publicado en: Journal of the Mechanical Behavior of Biomedical Materials 121 (2021), 104641
ISSN: 1751-6161

Factor impacto JCR: 4.042 (2021)
Categ. JCR: ENGINEERING, BIOMEDICAL rank: 48 / 98 = 0.49 (2021) - Q2 - T2
Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 27 / 46 = 0.587 (2021) - Q3 - T2

Factor impacto CITESCORE: 6.6 - Materials Science (Q1) - Engineering (Q1)

Factor impacto SCIMAGO: 0.746 - Biomedical Engineering (Q2) - Biomaterials (Q2)

Financiación: info:eu-repo/grantAgreement/EC/H2020/722535/EU/Predictive models and simulations in bone regeneration: a multiscale patient-specific approach/CuraBone
Tipo y forma: Article
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)

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