Effect of haptic geometry in C-loop intraocular lenses on optical quality

Cabeza-Gil, I. (Universidad de Zaragoza) ; Pérez-Gracia, J. ; Remón, L. (Universidad de Zaragoza) ; Calvo, B. (Universidad de Zaragoza)

Resumen: The biomechanical stability of intraocular lenses (IOLs) must achieve high-quality optical performance and clinical outcomes after cataract surgery. For this reason, the quality and performance features of the IOLs should be previously analysed following the Standard ISO 11979-2 and ISO 11979-3. The ISO 11979-3 tries to reproduce the behaviour of the IOL in the capsular bag by compressing the lens between two clamps. With this test, it has been demonstrated that the haptic design is a crucial factor to obtain biomechanical stability. Hence, the main goal of this study was to design an aberration-free aspheric IOL and to study the influence of haptic geometry on the optical quality. For that purpose, 5 hydrophobic IOLs with different haptic design were manufactured and their biomechanical stability was compared experimentally and numerically. The IOLs were classified as stiff and flexible designs depending on their haptic geometry. The biomechanical response was measured by means of the compression force, the axial displacement, the angle of contact or contact area, the decentration, the tilt and the strain energy. The results suggest that in vitro and in silico compression tests present similar responses for the IOLs analysed. Furthermore, the flexible IOL designs presented better biomechanical stability than stiff designs. These results were correlated with the optical performance, where the optical quality decreases with worst biomechanical stability. This numerical methodology provides an indisputable advance regarding IOL designs, leading to reduce costs by exploring a feasible space of solutions during the product design process and prior to manufacturing.

Idioma: Inglés

DOI: 10.1016/j.jmbbm.2020.104165

Año: 2021

Publicado en: Journal of the Mechanical Behavior of Biomedical Materials 114 (2021), 104165 [8 pp]
ISSN: 1751-6161

Factor impacto JCR: 4.042 (2021)

Categ. JCR: ENGINEERING, BIOMEDICAL rank: 48 / 98 = 0.49 (2021) - Q2 - T2
Categ. JCR: MATERIALS SCIENCE, BIOMATERIALS rank: 27 / 45 = 0.6 (2021) - Q3 - T2

Factor impacto CITESCORE: 6.6 - Materials Science (Q1) - Engineering (Q1)

Factor impacto SCIMAGO: 0.746 - Biomedical Engineering (Q2) - Biomaterials (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R
Financiación: info:eu-repo/grantAgreement/ES/MCIU/DPI2017-84047-R
Financiación: info:eu-repo/grantAgreement/ES/MINECO/PRE2018-084021
Financiación: info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-SU8 Unit-CIBER-BBN

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Óptica (Dpto. Física Aplicada)
Área (Departamento): Área Mec.Med.Cont. y Teor.Est. (Dpto. Ingeniería Mecánica)