Altered DNA methylation in human placenta after (suspected) preterm labor

Schoorlemmer, J. ; Macias-Redondo, S. ; Strunk, M. ; Ramos-Ruiz, R. ; Calvo, P. (Universidad de Zaragoza) ; Benito, R. (Universidad de Zaragoza) ; Paules, C. ; Oros, D.

Resumen: Aim: The aim of this study was to determine if alterations in DNA methylation in the human placenta would support suspected preterm labor as a pathologic insult associated with diminished placental health.
Methods: We evaluated placental DNA methylation at seven loci differentially methylated in placental pathologies using targeted bisulfite sequencing, in placentas associated with preterm labor (term birth after suspected preterm labor [n = 15] and preterm birth [n = 15]), and controls (n = 15).
Results: DNA methylation levels at the NCAM1 and PLAGL1 loci in placentas associated with preterm labor did differ significantly (p < 0.05) from controls.
Discussion: Specific alterations in methylation patterns indicative of an unfavourable placental environment are associated with preterm labor per se and not restricted to preterm birth.

Idioma: Inglés

DOI: 10.2217/epi-2019-0346

Año: 2020

Publicado en: EPIGENOMICS 12, 20 (2020), [14 pp]
ISSN: 1750-1911

Factor impacto JCR: 4.778 (2020)

Categ. JCR: GENETICS & HEREDITY rank: 46 / 175 = 0.263 (2020) - Q2 - T1

Factor impacto SCIMAGO: 1.264 - Genetics (Q2) - Cancer Research (Q2)

Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/B05-17D-2018
Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/B77
Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/B87
Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón
Financiación: info:eu-repo/grantAgreement/ES/DGA-FEDER/Una manera de hacer Europa
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-ERDF/RETICS-RD12-0026
Financiación: info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI17-02208
Financiación: info:eu-repo/grantAgreement/ES/ISCIII/PI10-301

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Microbiología (Dpto. Microb.Ped.Radio.Sal.Pú.)
Área (Departamento): Área Obstetricia y Ginecología (Dpto. Cirugía)