000108664 001__ 108664
000108664 005__ 20211216104751.0
000108664 037__ $$aTAZ-TFM-2021-494
000108664 041__ $$aeng
000108664 1001_ $$aBescós Ramo, Sara
000108664 24200 $$aNanocarriers based on orthogonal clickable block-copolycarbonates
000108664 24500 $$aNanotransportadores basados en copolímeros bloque ortogonalmente funcionalizables mediante química "click"
000108664 260__ $$aZaragoza$$bUniversidad de Zaragoza$$c2021
000108664 506__ $$aby-nc-sa$$bCreative Commons$$c3.0$$uhttp://creativecommons.org/licenses/by-nc-sa/3.0/
000108664 520__ $$aAmphiphilic block copolymers are promising materials for drug delivery due to their ability to form self-assemblies in aqueous solution, which are able to both encapsulate and transport drugs. In order to specifically aim the target tissue, drugs’ release can be controlled if stimuli-responsive moieties are incorporated to the macromolecular structure. Polycarbonate-based copolymers have been studied as drug delivery systems because of their biocompatibility and biodegradability. The use of cyclic carbonates as monomers and their subsequent ring opening polymerization (ROP) provides a high control of molecular mass and dispersity. Moreover, those derived from 2,2-bis(hydroxymethyl)propionic acid (bis-MPA) enable the incorporation of functionality onto its carboxyl group and, through various post-polymerization stages, their modification with stimuli-responsive units can be developed.<br />The aim of this Final Master Project is the synthesis and characterization of amphiphilic and stimuli-responsive block copolycarbonates, as well as the study of their selfassembly in water to form polymeric aggregates. To this end, it has been developed a synthetic approach for orthogonal clickable block copolycarbonates, based on allylic and propargylic pendant groups, which are able to be selectively functionalized with hydrophilic/hydrophobic stimuli-responsive moieties by widely-reported click reactions.<br />For this purpose, ROP of MAC monomer has been studied in order to synthetize an allyl-based homopolymer, PMAC, which has been functionalized through radical thiolene reaction with hydrosoluble thiols. Consequently, hydrosoluble and thermoresponsive polymers that show LCST behavior have been prepared, proving that they can be useful as hydrophilic block in the preparation of block copolycarbonates. Moreover, copolymerization of PMAC homopolymer and MPC monomer and the subsequent orthogonal post-polymerization modifications have been carried out. The combination of CuAAC and radical thiol-ene reactions has leaded to the synthesis of thermoresponsive amphiphilic block copolycarbonates that show self-assembly in water, and to the preparation of amphiphilic and potentially thermo and light-responsive block copolycarbonates.<br /><br />
000108664 521__ $$aMáster en Materiales Nanoestructurados para Aplicaciones Nanotecnológicas (Nanostructured Materials for Nanotechnology Applications)
000108664 540__ $$aDerechos regulados por licencia Creative Commons
000108664 700__ $$aPiñol Lacambra, Milagros$$edir.
000108664 700__ $$aOriol Langa, Luis T.$$edir.
000108664 7102_ $$aUniversidad de Zaragoza$$bQuímica Orgánica$$cQuímica Orgánica
000108664 8560_ $$f736636@unizar.es
000108664 8564_ $$s2700294$$uhttps://zaguan.unizar.es/record/108664/files/TAZ-TFM-2021-494.pdf$$yMemoria (eng)
000108664 8564_ $$s6350295$$uhttps://zaguan.unizar.es/record/108664/files/TAZ-TFM-2021-494_ANE.pdf$$yAnexos (eng)
000108664 909CO $$ooai:zaguan.unizar.es:108664$$pdriver$$ptrabajos-fin-master
000108664 950__ $$a
000108664 951__ $$adeposita:2021-12-16
000108664 980__ $$aTAZ$$bTFM$$cCIEN
000108664 999__ $$a20210628103849.CREATION_DATE