000109067 001__ 109067
000109067 005__ 20231215090956.0
000109067 0247_ $$2doi$$a10.1111/opo.12876
000109067 0248_ $$2sideral$$a125155
000109067 037__ $$aART-2021-125155
000109067 041__ $$aeng
000109067 100__ $$0(orcid)0000-0001-8219-2365$$aCabeza-Gil, Iulen$$uUniversidad de Zaragoza
000109067 245__ $$aA validated finite element model to reproduce Helmholtz’s theory of accommodation: a powerful tool to investigate presbyopia
000109067 260__ $$c2021
000109067 5060_ $$aAccess copy available to the general public$$fUnrestricted
000109067 5203_ $$aPurpose
To reproduce human in vivo accommodation numerically. For that purpose, a finite element model specific for a 29-year-old subject was designed. Once the proposed numerical model was validated, the decrease in accommodative amplitude with age was simulated according to data available in the literature.
Methods
In contrast with previous studies, the non-accommodated eye condition was the reference configuration. Consequently, two aspects were specifically highlighted: contraction of the ciliary muscle, which was simulated by a continuum electro-mechanical model and incorporation of initial lens capsule stresses, which allowed the lens to become accommodated after releasing the resting zonular tension.
Results
The morphological changes and contraction of the ciliary muscle were calibrated accurately according to the experimental data from the literature. All dynamic optical and biometric lens measurements validated the model. With the proposed numerical model, presbyopia was successfully simulated.
Conclusions
The most widespread theory of accommodation, proposed by Helmholtz, was simulated accurately. Assuming the same initial stresses in the lens capsule over time, stiffening of the lens nucleus is the main cause of presbyopia.
000109067 536__ $$9info:eu-repo/grantAgreement/ES/MCIU/DPI2017-84047-R
000109067 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000109067 590__ $$a3.992$$b2021
000109067 592__ $$a1.051$$b2021
000109067 594__ $$a4.1$$b2021
000109067 591__ $$aOPHTHALMOLOGY$$b17 / 62 = 0.274$$c2021$$dQ2$$eT1
000109067 593__ $$aOptometry$$c2021$$dQ1
000109067 593__ $$aOphthalmology$$c2021$$dQ1
000109067 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000109067 700__ $$0(orcid)0000-0002-6870-0594$$aGrasa, Jorge$$uUniversidad de Zaragoza
000109067 700__ $$0(orcid)0000-0001-9713-1813$$aCalvo, Begoña$$uUniversidad de Zaragoza
000109067 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000109067 773__ $$g41, 6 (2021), 1241-1253$$pOphthalmic physiol. opt.$$tOPHTHALMIC AND PHYSIOLOGICAL OPTICS$$x0275-5408
000109067 8564_ $$s2750503$$uhttps://zaguan.unizar.es/record/109067/files/texto_completo.pdf$$yVersión publicada
000109067 8564_ $$s2141633$$uhttps://zaguan.unizar.es/record/109067/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000109067 909CO $$ooai:zaguan.unizar.es:109067$$particulos$$pdriver
000109067 951__ $$a2023-12-15-09:00:03
000109067 980__ $$aARTICLE