On-POM Ring-Opening Polymerisation of N-Carboxyanhydrides

Soria-Carrera, H. ; Franco-Castillo, I. ; Romero, P. ; Martin, S. (Universidad de Zaragoza) ; de la Fuente, J.M. ; Mitchell, S.G. ; Martin-Rapun, R. (Universidad de Zaragoza)

Resumen: The ring-opening polymerisation of a-amino acid N-carboxyanhydrides (NCAs) offers a simple and scalable route to polypeptides with predicted and narrow molecular weight distributions. Here we show how polyoxometalates (POMs)-redox-active molecular metal-oxide anions-can serve as inorganic scaffold initiators for such NCA polymerisations. This "On-POM polymerisation" strategy serves as an innovative platform to design hybrid materials with additive or synergistic properties stemming from the inorganic and polypeptide component parts. We have used this synthetic approach to synthesise a library of bactericidal poly(lysine)-POM hybrid derivatives that can be used to prevent biofilm formation. This versatile "On-POM polymerisation" method provides a flexible synthetic approach for combining inorganic scaffolds with amino acids, and the potential to tailor and improve the specificity and performance of hybrid antimicrobial materials.

Idioma: Inglés

DOI: 10.1002/anie.202013563

Año: 2021

Publicado en: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 60, 7 (2021), 3449-3453
ISSN: 1433-7851

Factor impacto JCR: 16.823 (2021)

Categ. JCR: CHEMISTRY, MULTIDISCIPLINARY rank: 15 / 180 = 0.083 (2021) - Q1 - T1

Factor impacto CITESCORE: 23.9 - Chemical Engineering (Q1)

Factor impacto SCIMAGO: 5.126 - Chemistry (miscellaneous) (Q1) - Catalysis (Q1)

Financiación: info:eu-repo/grantAgreement/ES/CSIC/i-Link+2019-LINK20270
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/CIBER-BBN
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E15-20R
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E31-17R
Financiación: info:eu-repo/grantAgreement/ES/DGA-FSE/E47-20R
Financiación: info:eu-repo/grantAgreement/ES/MCIU/PGC2018-097583-B-I00
Financiación: info:eu-repo/grantAgreement/ES/MCIU/PID2019-105881RB-I00
Financiación: info:eu-repo/grantAgreement/ES/MCIU/PID2019-109333RB-I00
Financiación: info:eu-repo/grantAgreement/ES/MCIU/RYC-2013-12570

Tipo y forma: Article (PostPrint)

Área (Departamento): Área Química Orgánica (Dpto. Química Orgánica)
Área (Departamento): Área Química Física (Dpto. Química Física)